Literature summary for 5.3.99.3 extracted from

Kamei, D.; Murakami, M.; Sasaki, Y.; Nakatani, Y.; Majima, M.; Ishikawa, Y.; Ishii, T.; Uematsu, S.; Akira, S.; Hara, S.; Kudo, I.
Microsomal prostaglandin E synthase-1 in both cancer cells and hosts contributes to tumour growth, invasion and metastasis (2010), Biochem. J., 425, 361-371.

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Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
microsome	-	Mus musculus	-	-

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
Lewis lung carcinoma cell	-	Mus musculus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
Prostaglandin H2	-	Mus musculus	Prostaglandin E2	-	?

Synonyms

Synonyms	Comment	Organism
microsomal prostaglandin E synthase-1	-	Mus musculus
mPGES-1	-	Mus musculus

General Information

General Information	Comment	Organism
malfunction	small interfering RNA silencing of mPGES-1 in Lewis lung carcinoma cells decreases prostaglandin E2 synthesis markedly, accompanied by reduced cell proliferation, attenuated Matrigel invasiveness and increased extracellular matrix adhesion, while mPGES-1-overexpression shows increased proliferating and invasive capacities	Mus musculus

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Release 2023.1 (January 2023)