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Literature summary for 5.3.99.3 extracted from

  • Sandee, D.; Sivanuntakorn, S.; Vichai, V.; Kramyu, J.; Kirtikara, K.
    Up-regulation of microsomal prostaglandin E synthase-1 in COX-1 and COX-2 knock-out mouse fibroblast cell lines (2009), Prostaglandins Other Lipid Mediat., 88, 111-116.
    View publication on PubMed
Search for more literature for 5.3.99.3

Activating Compound

Activating Compound Comment Organism Structure
additional information mPGES-1 expression is upregulated in COX-1 and COX-2 knock-out cells Mus musculus

Application

Application Comment Organism
medicine mPGES-1 could be a potential therapeutic target of novel inhibitors for treatment of inflammatory diseases Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate Mus musculus
-
 (5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
fibroblast cell line
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate
-
 Mus musculus (5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate
-
 ?

Synonyms

Synonyms Comment Organism
microsomal prostaglandin E synthase-1
-
 Mus musculus
mPGES-1
-
 Mus musculus