Application | Comment | Organism |
---|---|---|
medicine | MPGES1 has been implicated in a number of human diseases or pathological conditions, such as rheumatoid arthritis, fever, and pain, and is therefore regarded as a primary target for development of novel antiinflammatory drugs | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
expression in Escherichia coli cells | Homo sapiens |
Crystallization (Comment) | Organism |
---|---|
the structure of human MPGES1 is determined in complex with the tripeptide gamma-L-glutamyl-L-cysteinyl-glycine, glutathione, at 3.5 A in-plane resolution using electron crystallography | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
E66A | mutant, fraction of wild-type activity, 53% | Homo sapiens |
E77A | mutant, no activity | Homo sapiens |
H72A | mutant, fraction of wild-type activity, 32% | Homo sapiens |
R110A | mutant, no activity | Homo sapiens |
R110S | mutant, no activity | Homo sapiens |
R67A | mutant, no activity | Homo sapiens |
R70A | mutant, fraction of wild-type activity, 58% | Homo sapiens |
R70A/Y117A | mutant, fraction of wild-type activity, 7% | Homo sapiens |
R70S | mutant, full activity | Homo sapiens |
Y117A | mutant, fraction of wild-type activity, 1% | Homo sapiens |
Y117F | mutant, full activity | Homo sapiens |
Y130I | mutant, fraction of wild-type activity, 15% | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | - |
Homo sapiens | 16020 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate | Homo sapiens | - |
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | O14684 | - |
- |
Purification (Comment) | Organism |
---|---|
- |
Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate | - |
Homo sapiens | (5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate | - |
? |
Subunits | Comment | Organism |
---|---|---|
homotrimer | - |
Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
microsomal prostaglandin E synthase-1 | - |
Homo sapiens |
MPGES1 | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
glutathione | - |
Homo sapiens |