Activating Compound | Comment | Organism | Structure |
---|---|---|---|
lipopolysaccharide | lipopolysaccharide binds to receptor TLR4 on osteoblasts that directly induces isoform mPGES-1 expression for prostaglandin E2 synthesis, leading to subsequent bone resorption | Mus musculus |
Application | Comment | Organism |
---|---|---|
medicine | use of isoform mPGES-1 as a target for the treatment of inflammatory bone disease | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | isoform mPGES-1 knockout mice. Contrary to wild-type, in knock-out animals no prostaglandin E2 production is found in osteoblast after administration of LPS. While in wild-type, LPS reduces the bone volume in femur associated with an increased number of osteoclasts, this loss is reduced in knock-out mice. LPS induces the loss of alveolar bone in wild-type, but not in the mutants | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
isoform mPGES-1 | - |