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Literature summary for 5.3.99.3 extracted from

  • Hayakawa, T.; Fujiwara, Y.; Hamaguchi, M.; Sugawa, T.; Okuyama, M.; Sasaki, E.; Watanabe, T.; Tominaga, K.; Oshitani, N.; Higuchi, K.; Arakawa, T.
    Roles of cyclooxygenase 2 and microsomal prostaglandin E synthase 1 in rat acid reflux oesophagitis (2006), Gut, 55, 450-456.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine prostaglandin E2 derived from COX-2 and isoform mPGES-1 plays a significant role in the pathogenesis of chronic acid reflux oesophagitis, and possibly in basal hyperplasia and persistent inflammatory cell infiltration Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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after induction of acid reflux oesophagitis. Expression of COX-2 and enzyme isoform mPGES-1 are markedly increased in oesophagitis and co-localize in epithelial cells of the basal layer, as well as inflammatory and mesenchymal cells in the lamina propria and submucosa
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Source Tissue

Source Tissue Comment Organism Textmining
epithelium epithelial cells of the basal layer, co-localization of isoform mPGES-1 and COX-2 after induction of oesophagitis Rattus norvegicus
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mesenchyme mesenchymal cells of the basal layer, co-localization of isoform mPGES-1 and COX-2 after induction of oesophagitis Rattus norvegicus
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