Application | Comment | Organism |
---|---|---|
medicine | prostaglandin E2 derived from COX-2 and isoform mPGES-1 plays a significant role in the pathogenesis of chronic acid reflux oesophagitis, and possibly in basal hyperplasia and persistent inflammatory cell infiltration | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
after induction of acid reflux oesophagitis. Expression of COX-2 and enzyme isoform mPGES-1 are markedly increased in oesophagitis and co-localize in epithelial cells of the basal layer, as well as inflammatory and mesenchymal cells in the lamina propria and submucosa | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
epithelium | epithelial cells of the basal layer, co-localization of isoform mPGES-1 and COX-2 after induction of oesophagitis | Rattus norvegicus | - |
mesenchyme | mesenchymal cells of the basal layer, co-localization of isoform mPGES-1 and COX-2 after induction of oesophagitis | Rattus norvegicus | - |