Literature summary for 5.3.99.3 extracted from

Bage, T.; Modeer, T.; Kawakami, T.; Quezada, H.C.; Yucel-Lindberg, T.
Regulation of prostaglandin E synthases: effects of siRNA-mediated inhibition of microsomal prostaglandin E synthase-1 (2007), Biochim. Biophys. Acta, 1773, 1589-1598.

Search for more literature for 5.3.99.3

Activating Compound

Activating Compound	Comment	Organism	Structure
interleukin 1beta	increase in protein expression and activity of isoform mPGES-1, accompanied by increased COX-2 expression and production of prostaglandin E2	Homo sapiens
Tumor necrosis factor alpha	increase in protein expression and activity of isoform mPGES-1, accompanied by increased COX-2 expression and production of prostaglandin E2	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
additional information	knockdown of isoform mPGES-1 by siRNA results in downregulation of cytokine-induced mPGES-1 protein expression and activity. siRNA does not affect the cytokine-stimulated production of prostaglandin E2, whereas prostaglandin F2alpha levels are enhanced. Neither isoform mPGES-2 nor cPGES expression are affected by siRNA silencing of mPGES-1	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
dexamethasone	inhibition of cytokine-induced expression of isoform mPGES-1, while isoforms mPGES-2 and cPGES remain unaffected	Homo sapiens
MK-886	inhibition of cytokine-induced expression of isoform mPGES-1, while isoforms mPGES-2 and cPGES remain unaffected	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytosol	-	Homo sapiens	5829	-
microsome	-	Homo sapiens	-	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	isoforms mPGES-1, mPGES-2 and cPGES	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
fibroblast	gingival fibroblast	Homo sapiens	-

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Release 2023.1 (January 2023)