Activating Compound | Comment | Organism | Structure |
---|---|---|---|
glutathione | - |
Homo sapiens | |
additional information | proinflammatory cytokinin, induction of the enzyme | Homo sapiens |
Application | Comment | Organism |
---|---|---|
drug development | the enzyme constitues an attractive drug target for treatment of inflammatory diseases | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
expression in Escherichia coli | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | glucocorticosteroids, down-regulation of the enzyme | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.16 | - |
prostaglandin H2 | - |
Homo sapiens | |
0.16 | - |
prostaglandin G2 | - |
Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Homo sapiens | - |
- |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
215000 | - |
gradient centrifugation, density equilibrium centrifugation, gel filtration | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
additional information | in patients with rheumatoid arthritis, the protein is overexpressed in synovial tissue, particularly by macrophages and fibroblasts in the synovial lining layer | Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
100 | 200 | in the presence of 0.4 mM prostaglandin H2 or prostaglandin G2 and 2.5 mM glutatione | Homo sapiens |
510 | - |
in the presence of 10 microM prostaglandin H2 or prostaglandin G2 and 2.5 mM glutatione | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
prostaglandin G2 | at pH 7.5, 2.5 mM glutathione and 10 microM substrate | Homo sapiens | 15-hydroperoxy-prostaglandin E2 | - |
? | |
Prostaglandin H2 | at pH 7.5, 2.5 mM glutathione and 10 microM substrate | Homo sapiens | Prostaglandin E2 | - |
? |
Subunits | Comment | Organism |
---|---|---|
trimer | 3 * ?, gradient centrifugation, density equilibrium centrifugation, gel filtration | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
MPGES1 | - |
Homo sapiens |
prostaglandin E synthase 1 | - |
Homo sapiens |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
50 | - |
prostaglandin H2 | - |
Homo sapiens | |
75 | - |
prostaglandin G2 | - |
Homo sapiens |