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Literature summary for 5.3.99.3 extracted from
- Human microsomal prostaglandin E synthase 1: a member of the MAPEG protein superfamily (2005), Methods Enzymol., 401, 147-161.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| glutathione | - |
Homo sapiens |  |
| additional information | proinflammatory cytokinin, induction of the enzyme | Homo sapiens |
Application
| Application | Comment | Organism |
|---|---|---|
| drug development | the enzyme constitues an attractive drug target for treatment of inflammatory diseases | Homo sapiens |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression in Escherichia coli | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| additional information | glucocorticosteroids, down-regulation of the enzyme | Homo sapiens |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.16 | - |
prostaglandin H2 | - |
Homo sapiens | |
| 0.16 | - |
prostaglandin G2 | - |
Homo sapiens | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | - |
Homo sapiens | - |
- |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 215000 | - |
gradient centrifugation, density equilibrium centrifugation, gel filtration | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| additional information | in patients with rheumatoid arthritis, the protein is overexpressed in synovial tissue, particularly by macrophages and fibroblasts in the synovial lining layer | Homo sapiens | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 100 | 200 | in the presence of 0.4 mM prostaglandin H2 or prostaglandin G2 and 2.5 mM glutatione | Homo sapiens |
| 510 | - |
in the presence of 10 microM prostaglandin H2 or prostaglandin G2 and 2.5 mM glutatione | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| prostaglandin G2 | at pH 7.5, 2.5 mM glutathione and 10 microM substrate | Homo sapiens | 15-hydroperoxy-prostaglandin E2 | - |
? | |
| Prostaglandin H2 | at pH 7.5, 2.5 mM glutathione and 10 microM substrate | Homo sapiens | Prostaglandin E2 | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| trimer | 3 * ?, gradient centrifugation, density equilibrium centrifugation, gel filtration | Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| MPGES1 | - |
Homo sapiens |
| prostaglandin E synthase 1 | - |
Homo sapiens |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 50 | - |
prostaglandin H2 | - |
Homo sapiens | |
| 75 | - |
prostaglandin G2 | - |
Homo sapiens | |
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Release 2023.1 (January 2023)
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