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Literature summary for 5.3.99.2 extracted from

  • Mathurin, K.; Gallant, M.A.; Germain, P.; Allard-Chamard, H.; Brisson, J.; Iorio-Morin, C.; de Brum Fernandes, A.; Caron, M.G.; Laporte, S.A.; Parent, J.L.
    An interaction between L-prostaglandin D synthase and arrestin increases PGD2 production (2011), J. Biol. Chem., 286, 2696-2706.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 5.3.99.2

Activating Compound

Activating Compound Comment Organism Structure
arrestin-3 arrestin-3 promotes prostaglandin D2 production by L-PGDS in vitro. Incubation of L-PGDS with arrestin-3 amino acids 56-100 enhances prostaglandin D2 production by 145% Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli C41(DE3) cells Mus musculus
expressed in Escherichia coli C41(DE3) cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
SeCl4
-
 Homo sapiens
SeCl4
-
 Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
 Mus musculus 5737
-
cytoplasm
-
 Homo sapiens 5737
-
nucleus perinuclear L-type prostaglandin synthase/arrestin-3 co-localization is observed in prostaglandin D2-producing MG-63 cells Homo sapiens 5634
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
25000
-
 SDS-PAGE Mus musculus
25000
-
 SDS-PAGE Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
Ni-NTA agarose column chromatography and glutathione-Sepharose column chromatography Mus musculus
Ni-NTA agarose column chromatography and glutathione-Sepharose column chromatography Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
MEF cell
-
 Mus musculus
-
MG-63 cell
-
 Homo sapiens
-
osteoblast
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Prostaglandin H2
-
 Mus musculus Prostaglandin D2
-
 ?
Prostaglandin H2
-
 Homo sapiens Prostaglandin D2
-
 ?

Synonyms

Synonyms Comment Organism
L-PGDS also called beta-trace Mus musculus
L-PGDS also called beta-trace Homo sapiens
L-prostaglandin D synthase
-
 Mus musculus
L-prostaglandin D synthase
-
 Homo sapiens
L-type prostaglandin synthase
-
 Mus musculus
L-type prostaglandin synthase
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
additional information L-PGDS is glutathione-independent Mus musculus
additional information L-PGDS is glutathione-independent Homo sapiens

General Information

General Information Comment Organism
malfunction co-localization of arrestin-3 with L-PGDS is drastically reduced in MG-63 cells when L-PGDS activity is inhibited Homo sapiens