Literature summary for 5.3.99.2 extracted from

Trivedi, S.G.; Newson, J.; Rajakariar, R.; Jacques, T.S.; Hannon, R.; Kanaoka, Y.; Eguchi, N.; Colville-Nash, P.; Gilroy, D.W.
Essential role for hematopoietic prostaglandin D2 synthase in the control of delayed type hypersensitivity (2006), Proc. Natl. Acad. Sci. USA, 103, 5179-5184.

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Application

Application	Comment	Organism
medicine	hematopoietic prostaglandin D2 synthase derived prostaglandins may protect against inflammatory diseases, where T-lymphocytes play a pathogenic role, as in rheumatoid arthritis, atopic eczema, and chronic rejection	Mus musculus

Protein Variants

Protein Variants	Comment	Organism
additional information	enzyme knockout animals and transgenic animals. Knockout mice display a more severe inflammatory response that fails to resolve, whereas transgenic mice have little detectable inflammation. Lymphocytes isolated from inguinal lymph nodes of knockout mice show hyperproliferation and increased IL-2 synthesis effects that are rescued by 15-deoxy-DELTA12,14-prostaglandin J2, but not prostaglandin D2	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	hematopoietic prostaglandin D2 synthase	-

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Release 2023.1 (January 2023)