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Literature summary for 5.3.99.2 extracted from

  • Beuckmann, C.T.; Aoyagi, M.; Okazaki, I.; Hiroike, T.; Toh, H.; Hayaishi, O.; Urade, Y.
    Binding of biliverdin, bilirubin, and thyroid hormones to lipocalin-type prostaglandin D synthase (1999), Biochemistry, 38, 8006-8013.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
3,3',5'-triiodo-L-thyronine 0.0093 mM, 50% inhibition Rattus norvegicus
3,3',5-triiodo-L-thyronine 0.011 mM, 50% inhibition Rattus norvegicus
bilirubin 0.0068 mM, 50% inhibition Rattus norvegicus
Biliverdin 0.0053 mM, 50% inhibition Rattus norvegicus
L-thyroxine 0.0039 mM, 50% inhibition, noncompetitve inhibition Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate Rattus norvegicus
-
(5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
recombinant PGDS-glutathione transferase fusion protein Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate
-
Rattus norvegicus (5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate
-
?

Synonyms

Synonyms Comment Organism
lipocalin-type prostaglandin d synthase
-
Rattus norvegicus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.023
-
L-thyroxine
-
Rattus norvegicus