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Literature summary for 5.3.4.1 extracted from

  • Xu, L.R.; Liu, X.L.; Chen, J.; Liang, Y.
    Protein disulfide isomerase interacts with tau protein and inhibits its fibrillization (2013), PLoS ONE, 8, e76657.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 5.3.4.1

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21 (DE3) pLysS cells Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
Ni Sepharose column chromatography Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
neuroblastoma cell
-
 Homo sapiens
-
SH-SY5Y cell
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
PDI
-
 Homo sapiens
protein disulfide isomerase
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function protein disulfide isomerase interacts with tau protein and physiologically inhibits its fibrillization mainly through ist thioredoxin-like catalytic domain a, forming a 1:1 complex and preventing Tau misfolding. Protein disulfide isomerase is both an enzyme and a chaperone, and implicated in neuroprotection against Alzheimer disease Homo sapiens