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Literature summary for 5.3.4.1 extracted from

  • Haefliger, S.; Klebig, C.; Schaubitzer, K.; Schardt, J.; Timchenko, N.; Mueller, B.U.; Pabst, T.
    Protein disulfide isomerase blocks CEBPA translation and is up-regulated during the unfolded protein response in AML (2011), Blood, 117, 5931-5940.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 5.3.4.1

Cloned(Commentary)

Cloned (Comment) Organism
expressed in H-1299 lung cancer cells Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum
-
 Homo sapiens 5783
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
55000
-
 x * 55000, SDS-PAGE Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HL-60 cell
-
 Homo sapiens
-
myeloid leukemia cell
-
 Homo sapiens
-
U-937 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information PDI directly interacts with calreticulin Homo sapiens ?
-
 ?

Subunits

Subunits Comment Organism
? x * 55000, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
PDI
-
 Homo sapiens
protein disulfide isomerase
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens protein disulfide isomerase is up-regulated during the unfolded protein response in acute myeloid leukemia. PDI is up-regulated in U-937 cells after induction of endoplasmic reticulum stress up

General Information

General Information Comment Organism
physiological function protein disulfide isomerase blocks transcription factor C/EBP-alpha translation but not transcription Homo sapiens