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Literature summary for 5.3.4.1 extracted from

  • Tamang, D.L.; Alves, B.N.; Elliott, V.; Redelman, D.; Wadhwa, R.; Fraser, S.A.; Hudig, D.
    Regulation of perforin lysis: implications for protein disulfide isomerase proteins (2009), Cell. Immunol., 255, 82-92.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 5.3.4.1

Inhibitors

Inhibitors Comment Organism Structure
additional information no inhibition of CxPR2 activity by treatment with cysteine and serine protease inhibitors E-64 and DCI Mus musculus
additional information CxRP2 activity is partially depleted by immobilized RNK-16 granule proteins, no inhibition of CxPR2 activity by treatment with cysteine and serine protease inhibitors E-64 and DCI Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytotoxic granule
-
 Rattus norvegicus
-
-
cytotoxic granule
-
 Mus musculus
-
-
endoplasmic reticulum
-
 Rattus norvegicus 5783
-
endoplasmic reticulum
-
 Mus musculus 5783
-

Metals/Ions

Metals/Ions Comment Organism Structure
additional information no effect by Ca2+ Rattus norvegicus
additional information no effect by Ca2+ Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus PDIA1, and probably also PDIA3, shows cytotoxic regulatory protein 2, CxRP2, activity in T-cells, acting as perforin inhibitor associated with cytotoxic T cell granules, overview. Perforin is a membrane-permeabilizing protein important to T cell cytotoxic action ?
-
 ?
additional information Mus musculus PDIA1, and probably also PDIA3, shows cytotoxic regulatory protein 2, CxRP2, activity in T-cells, acting as perforin inhibitor associated with cytotoxic T cell granules, overview. Perforin is a membrane-permeabilizing protein important to T cell cytotoxic action ?
-
 ?
additional information Mus musculus C57BL/6 PDIA1, and probably also PDIA3, shows cytotoxic regulatory protein 2, CxRP2, activity in T-cells, acting as perforin inhibitor associated with cytotoxic T cell granules, overview. Perforin is a membrane-permeabilizing protein important to T cell cytotoxic action ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus P27773 PDIA3; C57BL/6 mice
-
Mus musculus C57BL/6 P27773 PDIA3; C57BL/6 mice
-
Rattus norvegicus
-
 Fischer 344 rats
-

Source Tissue

Source Tissue Comment Organism Textmining
RNK-16 cell an NK cell-like leukemia cell line Rattus norvegicus
-
T-lymphocyte
-
 Rattus norvegicus
-
T-lymphocyte
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information PDIA1, and probably also PDIA3, shows cytotoxic regulatory protein 2, CxRP2, activity in T-cells, acting as perforin inhibitor associated with cytotoxic T cell granules, overview. Perforin is a membrane-permeabilizing protein important to T cell cytotoxic action Rattus norvegicus ?
-
 ?
additional information PDIA1, and probably also PDIA3, shows cytotoxic regulatory protein 2, CxRP2, activity in T-cells, acting as perforin inhibitor associated with cytotoxic T cell granules, overview. Perforin is a membrane-permeabilizing protein important to T cell cytotoxic action Mus musculus ?
-
 ?
additional information PDIA1, and probably also PDIA3, shows cytotoxic regulatory protein 2, CxRP2, activity in T-cells, acting as perforin inhibitor associated with cytotoxic T cell granules, overview. Perforin is a membrane-permeabilizing protein important to T cell cytotoxic action Mus musculus C57BL/6 ?
-
 ?

Synonyms

Synonyms Comment Organism
protein disulfide isomerase
-
 Rattus norvegicus
protein disulfide isomerase
-
 Mus musculus
protein disulfide isomerase A1
-
 Rattus norvegicus
protein disulfide isomerase A3
-
 Rattus norvegicus
protein disulfide isomerase A3
-
 Mus musculus

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
70 75 CxRP2 is heat sensitive losing substantial activity after 30 min at 70-75 °C, overview Rattus norvegicus
70 75 CxRP2 is heat sensitive losing substantial activity after 30 min at 70-75°C, overview Mus musculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
 assay at Rattus norvegicus
7.5
-
 assay at Mus musculus