Literature summary for 5.3.4.1 extracted from
Horibe, T.; Kikuchi, M.; Kawakami, K.
Interaction of human protein disulfide isomerase and human P5 with drug compounds: Analysis using biosensor technology (2008), Process Biochem., 43, 1330-1337.
No PubMed abstract available
Cloned(Commentary)
Cloned (Comment) |
Organism |
expression in Escherichia coli |
Homo sapiens |
Protein Variants
Protein Variants |
Comment |
Organism |
additional information |
analysis of binding and dissociation constants of various antibiotics with PDI and PDI domain deletion mutants lacking domains abb', domains b'a'c, domains aba'c |
Homo sapiens |
Inhibitors
Inhibitors |
Comment |
Organism |
Structure |
gentamycin |
analysis of binding and dissociation constants with PDI and PDI domain deletion mutants |
Homo sapiens |
|
kanamycin |
analysis of binding and dissociation constants with PDI and PDI domain deletion mutants |
Homo sapiens |
|
neomycin |
analysis of binding and dissociation constants with PDI and PDI domain deletion mutants |
Homo sapiens |
|
paromomycin |
analysis of binding and dissociation constants with PDI and PDI domain deletion mutants |
Homo sapiens |
|
ribostamycin |
analysis of binding and dissociation constants with PDI and PDI domain deletion mutants |
Homo sapiens |
|
sisomycin |
analysis of binding and dissociation constants with PDI and PDI domain deletion mutants |
Homo sapiens |
|
streptomycin |
analysis of binding and dissociation constants with PDI and PDI domain deletion mutants |
Homo sapiens |
|
Vancomycin |
analysis of binding and dissociation constants with PDI and PDI domain deletion mutants |
Homo sapiens |
|
vincristine |
inhibits chaperone activity but not isomerase activity of both isoforms PDI and P5 in vitro. A 100:1 molar ratio of vincristine to enzyme is sufficient to almost completely inhibit chaperone activity |
Homo sapiens |
|
Organism
Organism |
UniProt |
Comment |
Textmining |
Homo sapiens |
- |
isoform PDI |
- |