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Literature summary for 5.3.4.1 extracted from

  • Horibe, T.; Kikuchi, M.; Kawakami, K.
    Interaction of human protein disulfide isomerase and human P5 with drug compounds: Analysis using biosensor technology (2008), Process Biochem., 43, 1330-1337.
No PubMed abstract available

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information analysis of binding and dissociation constants of various antibiotics with PDI and PDI domain deletion mutants lacking domains abb', domains b'a'c, domains aba'c Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
gentamycin analysis of binding and dissociation constants with PDI and PDI domain deletion mutants Homo sapiens
kanamycin analysis of binding and dissociation constants with PDI and PDI domain deletion mutants Homo sapiens
neomycin analysis of binding and dissociation constants with PDI and PDI domain deletion mutants Homo sapiens
paromomycin analysis of binding and dissociation constants with PDI and PDI domain deletion mutants Homo sapiens
ribostamycin analysis of binding and dissociation constants with PDI and PDI domain deletion mutants Homo sapiens
sisomycin analysis of binding and dissociation constants with PDI and PDI domain deletion mutants Homo sapiens
streptomycin analysis of binding and dissociation constants with PDI and PDI domain deletion mutants Homo sapiens
Vancomycin analysis of binding and dissociation constants with PDI and PDI domain deletion mutants Homo sapiens
vincristine inhibits chaperone activity but not isomerase activity of both isoforms PDI and P5 in vitro. A 100:1 molar ratio of vincristine to enzyme is sufficient to almost completely inhibit chaperone activity Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
isoform PDI
-