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Literature summary for 5.3.4.1 extracted from

  • Reinhardt, C.; von Bruehl, M.L.; Manukyan, D.; Grahl, L.; Lorenz, M.; Altmann, B.; Dlugai, S.; Hess, S.; Konrad, I.; Orschiedt, L.; Mackman, N.; Ruddock, L.; Massberg, S.; Engelmann, B.
    Protein disulfide isomerase acts as an injury response signal that enhances fibrin generation via tissue factor activation (2008), J. Clin. Invest., 118, 1110-1122.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine protein disulfide isomerase directly promotes initiator protein tissue factor-dependent fibrin production during thrombus formation in vivo. After endothelial denudation of carotid artery, enzyme is released at the injury site from adherent platelets and disrupted vessel walls. Inhibition of the enzyme decreases initiator protein tissue factor-triggered fibrin formation. Enzyme infusion increases fibrin generation at the injury site Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens protein disulfide isomerase contributes to the activation of cryptic initiator protein tissue factoron microvesicles in vitro ?
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?
additional information Mus musculus protein disulfide isomerase directly promotes initiator protein tissue factor-dependent fibrin production during thrombus formation in vivo ?
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?

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Mus musculus
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-
-

Source Tissue

Source Tissue Comment Organism Textmining
blood platelet
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Mus musculus
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blood platelet
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Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information protein disulfide isomerase contributes to the activation of cryptic initiator protein tissue factoron microvesicles in vitro Homo sapiens ?
-
?
additional information protein disulfide isomerase directly promotes initiator protein tissue factor-dependent fibrin production during thrombus formation in vivo Mus musculus ?
-
?
additional information enzyme converts initiator protein tissue factor cysteine residues from glutathionylated to disulfide state Mus musculus ?
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?
additional information reduced protein disulfide isomerase activates initiator protein tissue factor by isomerzation of a mixed disulfide and a free thiol to an intramolecular disulfide Homo sapiens ?
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?