Literature summary for 5.3.4.1 extracted from

Swiatkowska, M.; Szymanski, J.; Padula, G.; Cierniewski, C.S.
Interaction and functional association of protein disulfide isomerase with alphaVbeta3 integrin on endothelial cells (2008), FEBS J., 275, 1813-1823.

Search for more literature for 5.3.4.1

Cloned(Commentary)

Cloned (Comment)	Organism
transfection of EA.hy926 cells	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
additional information	transfection of EA.hy926 cells and exposure to Mn2+ results in the appearance of surface protein thiol groups, which can be found in PDI and integrin alphaVbeta3, both proteins colocalizing on the cellular surface, and the formation of the PDI-alphaVbeta3 complex, which dissociates upon reduction. The PDI-alphaVbeta3 complex induces conversion of the integrin to the ligand-competent high-affinity state	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
bacitracin	inhibition of protein disulfide isomerase. Treatment of Mn2+-treated endothelial cells abolishes the conversion of integrin alphaVbeta to the ligand-competent high-affinity state	Homo sapiens
MA3 018	inhibition of protein disulfide isomerase. Treatment of Mn2+-treated endothelial cells abolishes the conversion of integrin alphaVbeta to the ligand-competent high-affinity state	Homo sapiens
MA3 019	inhibition of protein disulfide isomerase. Treatment of Mn2+-treated endothelial cells abolishes the conversion of integrin alphaVbeta to the ligand-competent high-affinity state	Homo sapiens

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Mn2+	modulates the thiol isomerase activity of protein disulfide isomerase that is bound to integrin alphaVbeta3 and induces its transition to the ligand-competent state	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
from platelet	Homo sapiens

Source Tissue

Source Tissue	Comment	Organism	Textmining
platelet	-	Homo sapiens	-

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Release 2023.1 (January 2023)