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Literature summary for 5.3.4.1 extracted from
- Protein disulfide isomerase activity is essential for viability and extracellular matrix formation in the nematode Caenorhabditis elegans (2007), Dev. Biol., 308, 449-461.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| functional and mutational analysis of a conserved family of three PDIs in Caenorhabditis elegans | Caenorhabditis elegans |
| functional complementation of an enzyme-deficient PDI-2-mutant strain of Caenorhabditis elegans, overview | Homo sapiens |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | construction of a PDI-2 defective mutant, mutations in gene pdi-2 result in severe body morphology defects, uncoordinated movement, adult sterility, abnormal molting and aberrant collagen deposition, cuticle collagens are disrupted in pdi-2 mutants, role of PDI-2 in collagen biogenesis can be restored following complementation of the mutant with human PDI, complementation of the pdi-2 mutant phenotype requires intact thioredoxin active sites, overview | Caenorhabditis elegans |
| additional information | pdi-3(ka1) crosses with specific collagen and collagen enzyme mutants, three transgenic lines all express the spliced transgenic product, phenotypes and genotypes, overview | Caenorhabditis elegans |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Caenorhabditis elegans | PDI is a multifunctional protein required for many aspects of protein folding and transit through the endoplasmic reticulum, the PDI activity is essential for viability, collagen biogenesis and extracellular matrix formation, overview, all isozymes are synergistically essential for embryonic development in this nematode | ? | - |
? |  |
| additional information | Caenorhabditis elegans | PDI is a multifunctional protein required for many aspects of protein folding and transit through the endoplasmic reticulum, the PDI activity is essential for viability, collagen biogenesis and extracellular matrix formation, PDI-2 is required for the normal function of prolyl 4-hydroxylase, a key collagen-modifying enzyme, overview, PDI-2 is required for normal post-embryonic development, all isozymes are synergistically essential for embryonic development in this nematode | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Caenorhabditis elegans | - |
wild-type strain N2 and diverse mutant strains, overview, isozymes PDI-1 and PDI-3 encoded by genes pdi-1 and pdi-3 | - |
| Caenorhabditis elegans | - |
isozyme PDI-2; wild-type strain N2 and diverse mutant strains, overview, isozymes PDI-1, PDI-2 and PDI-3 encoded by genes pdi-1, pdi-2 and pdi-3 | - |
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| additional information | PDI-2 is required for normal post-embryonic development | Caenorhabditis elegans | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | PDI is a multifunctional protein required for many aspects of protein folding and transit through the endoplasmic reticulum, the PDI activity is essential for viability, collagen biogenesis and extracellular matrix formation, overview, all isozymes are synergistically essential for embryonic development in this nematode | Caenorhabditis elegans | ? | - |
? | |
| additional information | PDI is a multifunctional protein required for many aspects of protein folding and transit through the endoplasmic reticulum, the PDI activity is essential for viability, collagen biogenesis and extracellular matrix formation, PDI-2 is required for the normal function of prolyl 4-hydroxylase, a key collagen-modifying enzyme, overview, PDI-2 is required for normal post-embryonic development, all isozymes are synergistically essential for embryonic development in this nematode | Caenorhabditis elegans | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| More | isozyme domain structure, overview | Caenorhabditis elegans |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| PDI | - |
Homo sapiens |
| PDI | - |
Caenorhabditis elegans |
| protein disulfide isomerase | - |
Caenorhabditis elegans |
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