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Literature summary for 5.3.4.1 extracted from

  • Lappi, A.K.; Lensink, M.F.; Alanen, H.I.; Salo, K.E.H.; Lobell, M.; Juffer, A.H.; Ruddock, L.W.
    A conserved arginine plays a role in the catalytic cycle of the protein disulphide isomerases (2003), J. Mol. Biol., 335, 283-295.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Homo sapiens

Protein Variants

Protein Variants Comment Organism
R120D less than 2% of wild-type activity in NRCSQGSCWN oxidation assay Homo sapiens
R120K 71% of wild-type activity in NRCSQGSCWN oxidation assay Homo sapiens
R120Q 26% of wild-type activity in NRCSQGSCWN oxidation assay Homo sapiens
R120S 40% of wild-type activity in NRCSQGSCWN oxidation assay Homo sapiens
W128F 95% of wild-type activity in NRCSQGSCWN oxidation assay Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum
-
Homo sapiens 5783
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
NRCSQGSCWN
-
Homo sapiens NRCSQGSCWN
-
?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.5
-
R120Q mutant shows 59% of wild-type activity at pH 7.5 Homo sapiens

pH Range

pH Minimum pH Maximum Comment Organism
4.5 7.5 approx. 50% of maximal activity at pH 5.5, approx. 75% of maximal activity at pH 7.5 Homo sapiens