Cloned (Comment) | Organism |
---|---|
expression in Escherichia coli | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
R120D | less than 2% of wild-type activity in NRCSQGSCWN oxidation assay | Homo sapiens |
R120K | 71% of wild-type activity in NRCSQGSCWN oxidation assay | Homo sapiens |
R120Q | 26% of wild-type activity in NRCSQGSCWN oxidation assay | Homo sapiens |
R120S | 40% of wild-type activity in NRCSQGSCWN oxidation assay | Homo sapiens |
W128F | 95% of wild-type activity in NRCSQGSCWN oxidation assay | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
endoplasmic reticulum | - |
Homo sapiens | 5783 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
NRCSQGSCWN | - |
Homo sapiens | NRCSQGSCWN | - |
? |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
6.5 | - |
R120Q mutant shows 59% of wild-type activity at pH 7.5 | Homo sapiens |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
4.5 | 7.5 | approx. 50% of maximal activity at pH 5.5, approx. 75% of maximal activity at pH 7.5 | Homo sapiens |