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Literature summary for 5.3.3.5 extracted from

  • Grebenok, R.J.; Ohnmeiss, T.E.; Yamamoto, A.; Huntley, E.D.; Galbraith, D.W.; Della Penna, D.
    Isolation and characterization of an Arabidopsis thaliana C-8,7 sterol isomerase: functional and structural similarities to mammalian C-8,7 sterol isomerase/emopamil-binding protein (1998), Plant Mol. Biol., 38, 807-815.
    View publication on PubMed
Search for more literature for 5.3.3.5

Cloned(Commentary)

Cloned (Comment) Organism
the full-length cDNA that complements the erg2 mutation contains an open reading frame encoding a 21000 Da protein that shares 68% similarity and 35% amino acid identity to the recently isolated mouse C8,7 sterol isomerase Arabidopsis thaliana

Protein Variants

Protein Variants Comment Organism
additional information functional complementation by C-8,7 sterol isomerase of the corresponding sterol mutant in yeast and its characterization by exposure to sigma ligands. The full-length Arabidosis thaliana cDNA encoding C-8,7 sterol isomerase complements the erg2 mutation Arabidopsis thaliana

Inhibitors

Inhibitors Comment Organism Structure
haloperidol
-
 Arabidopsis thaliana
ifenprodil
-
 Arabidopsis thaliana
verapamil
-
 Arabidopsis thaliana

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane putative transmembrane spanning domains Arabidopsis thaliana 16020
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
21000
-
 x * 21000, about, sequence calculation Arabidopsis thaliana
26737
-
 x * 26737, calculation from nucleotide sequence Arabidopsis thaliana

Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4alpha-methyl-5alpha-ergosta-8,24-dien-3beta-ol
-
 Arabidopsis thaliana 24-methylenelophenol i.e. 4alpha-methyl-5alpha-ergosta-7,24-dien-3beta-ol ?

Subunits

Subunits Comment Organism
? x * 26737, calculation from nucleotide sequence Arabidopsis thaliana
? x * 21000, about, sequence calculation Arabidopsis thaliana

Synonyms

Synonyms Comment Organism
C-8,7 sterol isomerase
-
 Arabidopsis thaliana
SI1
-
 Arabidopsis thaliana

General Information

General Information Comment Organism
physiological function the enzyme is involved in the ergosterol production. Pharmacological relationship between sigma ligand-binding and C-8,7 sterol isomerase activity, the C-8,7 sterol isomerase that contains a sigma ligand binding site Arabidopsis thaliana