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Literature summary for 5.3.3.5 extracted from
- Pharmacological analysis of sterol DELTA8-DELTA7-isomerase proteins with [3H]ifenprodil (1998), Mol. Pharmacol., 54, 591-598.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| (+)-emopamil | - |
Cavia porcellus |  |
| (+)-emopamil | - |
Homo sapiens | |
| (+)-emopamil | - |
Mus musculus | |
| (+)-emopamil | - |
Saccharomyces cerevisiae | |
| (+)-verapamil | - |
Cavia porcellus | |
| (+)-verapamil | - |
Homo sapiens | |
| (+)-verapamil | - |
Mus musculus | |
| (+)-verapamil | - |
Saccharomyces cerevisiae | |
| (-)-emopamil | IC50: 28 nM for the liver enzyme, IC50: 34 nM for the brain enzyme | Cavia porcellus | |
| (-)-emopamil | - |
Homo sapiens | |
| (-)-emopamil | - |
Mus musculus | |
| (-)-emopamil | - |
Saccharomyces cerevisiae | |
| (-)-verapamil | - |
Cavia porcellus | |
| (-)-verapamil | - |
Homo sapiens | |
| (-)-verapamil | - |
Mus musculus | |
| (-)-verapamil | - |
Saccharomyces cerevisiae | |
| amiodarone | - |
Cavia porcellus | |
| amiodarone | - |
Homo sapiens | |
| amiodarone | - |
Mus musculus | |
| amiodarone | - |
Saccharomyces cerevisiae | |
| AY9944 | - |
Homo sapiens | |
| AY9944 | - |
Saccharomyces cerevisiae | |
| BM15766 | - |
Homo sapiens | |
| BM15766 | - |
Saccharomyces cerevisiae | |
| CuCl2 | IC50: 0.01 mM, ifenprodil-labeled enzyme | Cavia porcellus | |
| CuCl2 | IC50: 0.0023 mM, ifenprodil-labeled enzyme | Homo sapiens | |
| CuCl2 | IC50: 0.0011 mM, ifenprodil-labled enzyme | Mus musculus | |
| CuCl2 | IC50: 0.57 mM, ifenprodil-labeled enzyme | Saccharomyces cerevisiae | |
| ditolylguanidine | IC50: 122 nM for the liver enzyme, IC50: 36 nM for the brain enzyme | Cavia porcellus | |
| ditolylguanidine | - |
Homo sapiens | |
| ditolylguanidine | - |
Mus musculus | |
| ditolylguanidine | - |
Saccharomyces cerevisiae | |
| enclomiphene | - |
Homo sapiens | |
| enclomiphene | - |
Saccharomyces cerevisiae | |
| fenpropimorph | - |
Homo sapiens | |
| fenpropimorph | - |
Saccharomyces cerevisiae | |
| haloperidol | IC50: 6.8 nM for the liver enzyme, 23 nM for the brain enzyme | Cavia porcellus | |
| haloperidol | - |
Homo sapiens | |
| haloperidol | - |
Mus musculus | |
| haloperidol | - |
Saccharomyces cerevisiae | |
| ifenprodil | IC50: 2.4 nM for the liver enzyme, 1.7 nM for the brain enzyme | Cavia porcellus | |
| ifenprodil | - |
Homo sapiens | |
| L690404 | - |
Cavia porcellus | |
| L690404 | - |
Homo sapiens | |
| L690404 | - |
Mus musculus | |
| L690404 | - |
Saccharomyces cerevisiae | |
| MDL28815 | - |
Homo sapiens | |
| MDL28815 | - |
Saccharomyces cerevisiae | |
| MDL5332 | - |
Homo sapiens | |
| MDL5332 | - |
Saccharomyces cerevisiae | |
| nafoxidine | - |
Homo sapiens | |
| nafoxidine | - |
Saccharomyces cerevisiae | |
| naftifine | - |
Homo sapiens | |
| naftifine | - |
Saccharomyces cerevisiae | |
| opipramol | - |
Cavia porcellus | |
| opipramol | - |
Homo sapiens | |
| opipramol | - |
Mus musculus | |
| opipramol | - |
Saccharomyces cerevisiae | |
| tamoxifen | - |
Homo sapiens | |
| tamoxifen | - |
Saccharomyces cerevisiae | |
| terbinafine | - |
Homo sapiens | |
| terbinafine | - |
Saccharomyces cerevisiae | |
| tridemorph | - |
Homo sapiens | |
| tridemorph | - |
Saccharomyces cerevisiae | |
| Trifluoperazine | IC50: 11 nM for the liver enzyme, IC50: 13 nM for the brain enzyme | Cavia porcellus | |
| Trifluoperazine | - |
Homo sapiens | |
| Trifluoperazine | - |
Mus musculus | |
| Trifluoperazine | - |
Saccharomyces cerevisiae | |
| trifluoroperazine | - |
Homo sapiens | |
| trifluperidol | - |
Homo sapiens | |
| trifluperidol | - |
Saccharomyces cerevisiae | |
| Triparanol | - |
Homo sapiens | |
| Triparanol | - |
Saccharomyces cerevisiae | |
| U18666A | - |
Homo sapiens | |
| U18666A | - |
Saccharomyces cerevisiae | |
| verapamil | - |
Cavia porcellus | |
| verapamil | - |
Homo sapiens | |
| verapamil | - |
Mus musculus | |
| verapamil | - |
Saccharomyces cerevisiae | |
| ZnCl2 | IC50: 0.001 mM, ifenprodil-labeled enzyme | Cavia porcellus | |
| ZnCl2 | IC50: 0.0006 mM, ifenprodil-labeled enzyme | Homo sapiens | |
| ZnCl2 | IC50: 0.001 mM, ifenprodil-labeled enzyme | Mus musculus | |
| ZnCl2 | IC50: 0.0044 mM, ifenprodil-labeled enzyme | Saccharomyces cerevisiae | |
| zuclomiphene | - |
Homo sapiens | |
| zuclomiphene | - |
Saccharomyces cerevisiae | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Cavia porcellus | Q60490 | - |
- |
| Homo sapiens | Q15125 | - |
- |
| Mus musculus | P70245 | - |
- |
| Saccharomyces cerevisiae | - |
- |
- |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| DELTA8-DELTA7 isomerase | - |
Saccharomyces cerevisiae |
| DELTA8-DELTA7 isomerase | - |
Homo sapiens |
| DELTA8-DELTA7 isomerase | - |
Mus musculus |
| DELTA8-DELTA7 isomerase | - |
Cavia porcellus |
| ERG2p | - |
Saccharomyces cerevisiae |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0000001 | - |
U18666A | - |
Saccharomyces cerevisiae | |
| 0.0000005 | - |
MDL28815 | - |
Homo sapiens | |
| 0.00000067 | - |
MDL5332 | - |
Saccharomyces cerevisiae | |
| 0.00000069 | - |
enclomiphene | - |
Homo sapiens | |
| 0.0000009 | - |
nafoxidine | - |
Homo sapiens | |
| 0.000001 | - |
L690404 | - |
Cavia porcellus | |
| 0.0000013 | - |
tridemorph | - |
Homo sapiens | |
| 0.0000019 | - |
U18666A | - |
Homo sapiens | |
| 0.0000023 | - |
(+)-emopamil | - |
Cavia porcellus | |
| 0.0000023 | - |
L690404 | - |
Homo sapiens | |
| 0.0000028 | - |
tamoxifen | - |
Homo sapiens | |
| 0.000003 | - |
zuclomiphene | - |
Homo sapiens | |
| 0.0000036 | - |
Trifluoperazine | - |
Homo sapiens | |
| 0.0000038 | - |
opipramol | - |
Homo sapiens | |
| 0.0000039 | - |
trifluoroperazine | - |
Cavia porcellus | |
| 0.000006 | - |
ifenprodil | - |
Homo sapiens | |
| 0.0000077 | - |
Trifluoperazine | - |
Mus musculus | |
| 0.0000085 | - |
opipramol | - |
Cavia porcellus | |
| 0.00001 | - |
(-)-emopamil | - |
Cavia porcellus | |
| 0.000012 | - |
AY9944 | - |
Homo sapiens | |
| 0.000014 | - |
Triparanol | - |
Homo sapiens | |
| 0.000016 | - |
amiodarone | - |
Cavia porcellus | |
| 0.000019 | - |
(+)-emopamil | - |
Homo sapiens | |
| 0.00002 | - |
(-)-emopamil | - |
Homo sapiens | |
| 0.000023 | - |
(-)-emopamil | - |
Mus musculus | |
| 0.000035 | - |
haloperidol | - |
Homo sapiens | |
| 0.000035 | - |
amiodarone | - |
Homo sapiens | |
| 0.000044 | - |
fenpropimorph | - |
Homo sapiens | |
| 0.000047 | - |
opipramol | - |
Mus musculus | |
| 0.000054 | - |
MDL5332 | - |
Homo sapiens | |
| 0.00006 | - |
amiodarone | - |
Mus musculus | |
| 0.000077 | - |
(+)-emopamil | - |
Mus musculus | |
| 0.000232 | - |
nafoxidine | - |
Saccharomyces cerevisiae | |
| 0.00025 | - |
haloperidol | - |
Cavia porcellus | |
| 0.00031 | - |
naftifine | - |
Saccharomyces cerevisiae | |
| 0.000354 | - |
trifluperidol | - |
Homo sapiens | |
| 0.000435 | - |
haloperidol | - |
Mus musculus | |
| 0.00089 | - |
(+)-verapamil | - |
Cavia porcellus | |
| 0.0015 | - |
naftifine | - |
Homo sapiens | |
| 0.00152 | - |
(-)-verapamil | - |
Mus musculus | |
| 0.0019 | - |
U18666A | - |
Homo sapiens | |
| 0.00269 | - |
(-)-verapamil | - |
Homo sapiens | |
| 0.0029 | - |
(+)-verapamil | - |
Saccharomyces cerevisiae | |
| 0.0029 | - |
(-)-verapamil | - |
Cavia porcellus | |
| 0.00363 | - |
(+)-verapamil | - |
Mus musculus | |
| 0.00407 | - |
(+)-verapamil | - |
Homo sapiens | |
| 0.0043 | - |
ditolylguanidine | - |
Mus musculus | |
| 0.0106 | - |
ditolylguanidine | - |
Cavia porcellus | |
| 0.0144 | - |
ditolylguanidine | - |
Homo sapiens | |
| 0.01648 | - |
BM15766 | - |
Saccharomyces cerevisiae | |
| 0.034 | - |
BM15766 | - |
Homo sapiens | |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.0000017 | - |
1.7 nM for the brain enzyme | Cavia porcellus | ifenprodil | |
| 0.0000024 | - |
IC50: 2.4 nM for the liver enzyme | Cavia porcellus | ifenprodil | |
| 0.0000068 | - |
IC50: 6.8 nM for the liver enzyme | Cavia porcellus | haloperidol | |
| 0.000011 | - |
IC50: 11 nM for the liver enzyme | Cavia porcellus | Trifluoperazine | |
| 0.000013 | - |
IC50: 13 nM for the brain enzyme | Cavia porcellus | Trifluoperazine | |
| 0.000023 | - |
23 nM for the brain enzyme | Cavia porcellus | haloperidol | |
| 0.000028 | - |
IC50: 28 nM for the liver enzyme | Cavia porcellus | (-)-emopamil | |
| 0.000034 | - |
IC50: 34 nM for the brain enzyme | Cavia porcellus | (-)-emopamil | |
| 0.000036 | - |
IC50: 36 nM for the brain enzyme | Cavia porcellus | ditolylguanidine | |
| 0.000122 | - |
IC50: 122 nM for the liver enzyme | Cavia porcellus | ditolylguanidine | |
| 0.0006 | - |
IC50: 0.0006 mM, ifenprodil-labeled enzyme | Homo sapiens | ZnCl2 | |
| 0.001 | - |
IC50: 0.001 mM, ifenprodil-labeled enzyme | Mus musculus | ZnCl2 | |
| 0.001 | - |
IC50: 0.001 mM, ifenprodil-labeled enzyme | Cavia porcellus | ZnCl2 | |
| 0.0011 | - |
IC50: 0.0011 mM, ifenprodil-labled enzyme | Mus musculus | CuCl2 | |
| 0.0023 | - |
IC50: 0.0023 mM, ifenprodil-labeled enzyme | Homo sapiens | CuCl2 | |
| 0.0044 | - |
IC50: 0.0044 mM, ifenprodil-labeled enzyme | Saccharomyces cerevisiae | ZnCl2 | |
| 0.01 | - |
IC50: 0.01 mM, ifenprodil-labeled enzyme | Cavia porcellus | CuCl2 | |
| 0.57 | - |
IC50: 0.57 mM, ifenprodil-labeled enzyme | Saccharomyces cerevisiae | CuCl2 | |
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