Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | the enzyme is fully active in the absence of Mn2+ as long as Mg2+ is present in the buffer | Escherichia coli | |
Mn2+ | the enzyme is fully active in the absence of Mn2+ as long as Mg2+ is present in the buffer | Escherichia coli | |
Zinc | essential cofactor. Type I enzyme contains an atom of tinc. The metal is located in an unusual six-coordinate pocket and may facilitate protonation of the unactivated carbon-carbon double bond in isopentenyl diphosphate | Escherichia coli |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
type I isopentenyl-diphosphate D-isomerase | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | zinc is located in an unusual six-coordinate pocket and may facilitate protonation of the unactivated carbon-carbon double bond in isopentenyl diphosphate. The sulfhydryl moiety C67, perhaps in the thiolate form, is in position to remove a proton from the resulting tertiary carbocation to complete the reaction | Escherichia coli | ? | - |
? |