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Literature summary for 5.3.1.6 extracted from

  • Zhang, R.; Andersson, C.E.; Savchenko, A.; Skarina, T.; Evdokimova, E.; Beasley, S.; Arrowsmith, C.H.; Edwards, A.M.; Joachimiak, A.; Mowbray, S.L.
    Structure of Escherichia coli ribose-5-phosphate isomerase: a ubiquitous enzyme of the pentose phosphate pathway and the Calvin cycle (2003), Structure, 11, 31-42.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
overexpression as a His-tagged Se-Met-labeled protein Escherichia coli

Crystallization (Commentary)

Crystallization (Comment) Organism
hanging drop vapor diffusion method, structure of a complex with arabinose 5-phosphate at 1.25 A resolution Escherichia coli

Inhibitors

Inhibitors Comment Organism Structure
arabinose 5-phosphate
-
Escherichia coli
phosphate
-
Escherichia coli

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.1
-
D-ribose 5-phosphate
-
Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
D-ribose 5-phosphate Escherichia coli the enzyme plays essential roles in carbohydrate anabolism and catabolism D-ribulose 5-phosphate
-
r

Organism

Organism UniProt Comment Textmining
Escherichia coli P0A7Z0
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-ribose 5-diphosphate
-
Escherichia coli D-ribulose 5-diphosphate
-
?
D-ribose 5-phosphate
-
Escherichia coli D-ribulose 5-phosphate
-
r
D-ribose 5-phosphate the enzyme plays essential roles in carbohydrate anabolism and catabolism Escherichia coli D-ribulose 5-phosphate
-
r
D-ribose 5-triphosphate
-
Escherichia coli D-ribulose 5-triphosphate
-
?

Subunits

Subunits Comment Organism
dimer the two subunits in the dimer have different conformations, the result of motion of two largely rigid domains with respect to each other in the subunit Escherichia coli

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
2100
-
D-ribose 5-phosphate
-
Escherichia coli

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
8
-
phosphate
-
Escherichia coli