Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(1Z,2Z)-N,N'-dihydroxy-4-methylcyclohexa-3,5-diene-1,2-diimine | - |
Trypanosoma cruzi | |
(2E)-2-[(4-methyl-5-oxido-1,2,5-oxadiazol-3-yl)methylidene]hydrazinecarbothioamide | - |
Trypanosoma cruzi | |
(2E)-2-[(5-nitrofuran-2-yl)methylidene]hydrazinecarbothioamide | irreversible inhibitor | Trypanosoma cruzi | |
(2E)-2-[2-[(3-oxido-2,1,3-benzoxadiazol-5-yl)methoxy]benzylidene]-N-(prop-2-en-1-yl)hydrazinecarbothioamide | irreversible inhibitor | Trypanosoma cruzi | |
(2E)-N-(naphthalen-2-yl)-2-[(2E)-3-(5-nitrofuran-2-yl)prop-2-en-1-ylidene]hydrazinecarboxamide | irreversible inhibitor | Trypanosoma cruzi | |
(2E)-N-[2-(3,4-dimethoxyphenyl)ethyl]-2-[(5-nitrofuran-2-yl)methylidene]hydrazinecarboxamide | irreversible inhibitor | Trypanosoma cruzi | |
(4-methyl-1,2,3-thiadiazol-5-yl)methanol | 29% inhibition at 0.4 mM | Trypanosoma cruzi | |
1,2,4-thiadiazole | 59% inhibition at 0.1 mM | Homo sapiens | |
1,2,4-thiadiazole | - |
Trypanosoma cruzi | |
1,2,6-thiadiazine | irreversible inhibitor | Trypanosoma cruzi | |
1,3,4-oxathiazole | - |
Trypanosoma cruzi | |
2,6-dibenzyl-4-[(5-nitrothiophen-2-yl)methylidene]-1,2,6-thiadiazinane-3,5-dione 1,1-dioxide | irreversible inhibitor | Trypanosoma cruzi | |
2-phenyl-4H-chromen-4-one | - |
Trypanosoma cruzi | |
2-[(1E)-2-nitroprop-1-en-1-yl]thiophene | - |
Trypanosoma cruzi | |
2-[(3-aminophenyl)disulfanyl]aniline | - |
Trypanosoma cruzi | |
3,5-diphenyl-1,2,4-thiadiazole | 74% inhibition at 0.4 mM | Trypanosoma cruzi | |
3-(4-methylphenyl)-5-[(4-methylphenyl)sulfonyl]-1,2,4-thiadiazole | - |
Trypanosoma cruzi | |
3-nitrobiphenyl-4-amine | - |
Trypanosoma cruzi | |
4-(4-nitrobenzylidene)-2,6-bis(2-phenylethyl)-1,2,6-thiadiazinane-3,5-dione 1,1-dioxide | irreversible inhibitor, 85% inhibition at 0.4 mM | Trypanosoma cruzi | |
4-[(5-nitrofuran-2-yl)methylidene]-4H-1,2,6-thiadiazine-3,5-diamine 1,1-dioxide | irreversible inhibitor | Trypanosoma cruzi | |
4-[(5-nitrothiophen-2-yl)methylidene]-2,6-bis(2-phenylethyl)-1,2,6-thiadiazinane-3,5-dione 1,1-dioxide | irreversible inhibitor | Trypanosoma cruzi | |
5-[(1E)-2-nitroprop-1-en-1-yl]-1,3-benzodioxole | - |
Trypanosoma cruzi | |
6,6'-bi-1,3-benzothiazole-2,2'-diamine | - |
Trypanosoma cruzi | |
6-[(E)-2-(5-nitrothiophen-2-yl)ethenyl]-2,1,3-benzoxadiazole 1-oxide | irreversible inhibitor | Trypanosoma cruzi | |
6-[(E)-2-[(4-fluorophenyl)sulfanyl]ethenyl]-2,1,3-benzoxadiazole 1-oxide | irreversible inhibitor | Trypanosoma cruzi | |
8-bromo-5,10-dioxidophenazin-2-yl chloroacetate | 50% inhibition at 0.4 mM | Trypanosoma cruzi | |
ethyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl)-1,2,4-thiadiazole-5-carboxylate | - |
Trypanosoma cruzi | |
ethyl 3-phenyl-1,2,4-thiadiazole-5-carboxylate | - |
Trypanosoma cruzi | |
additional information | not inhibited by 1,2,6-thiadiazine, phenazine 5,9-dioxide, and 1,3,4-oxathiazole | Homo sapiens | |
N-[(2-oxido-4-phenyl-1,2,5-oxadiazol-3-yl)methyl]naphthalen-1-amine | 72% inhibition at 0.4 mM | Trypanosoma cruzi | |
N-[(4-methyl-5-oxido-1,2,5-oxadiazol-3-yl)methyl]naphthalen-1-amine | 41% inhibition at 0.4 mM | Trypanosoma cruzi | |
phenazine 5,9-dioxide | 84% inhibition at 0.4 mM | Trypanosoma cruzi |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Trypanosoma cruzi | - |
- |
- |
Trypanosoma cruzi T2 | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-glyceraldehyde 3-phosphate | - |
Homo sapiens | dihydroxyacetone phosphate | - |
? | |
D-glyceraldehyde 3-phosphate | - |
Trypanosoma cruzi | dihydroxyacetone phosphate | - |
? | |
D-glyceraldehyde 3-phosphate | - |
Trypanosoma cruzi T2 | dihydroxyacetone phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
TIM | - |
Homo sapiens |
TIM | - |
Trypanosoma cruzi |
Triosephosphate isomerase | - |
Homo sapiens |
Triosephosphate isomerase | - |
Trypanosoma cruzi |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0035 | - |
in 100 mM triethanolamine, 10 mM EDTA, pH 7.4 and 10% of dimethyl sulfoxide, at 36°C | Trypanosoma cruzi | 1,2,4-thiadiazole | |
0.01 | - |
in 100 mM triethanolamine, 10 mM EDTA, pH 7.4 and 10% of dimethyl sulfoxide, at 36°C | Trypanosoma cruzi | 1,3,4-oxathiazole | |
0.013 | - |
in 100 mM triethanolamine, 10 mM EDTA, pH 7.4 and 10% of dimethyl sulfoxide, at 36°C | Trypanosoma cruzi | 1,2,6-thiadiazine | |
0.02 | - |
in 100 mM triethanolamine, 10 mM EDTA, pH 7.4 and 10% of dimethyl sulfoxide, at 36°C | Trypanosoma cruzi | 4-[(5-nitrofuran-2-yl)methylidene]-4H-1,2,6-thiadiazine-3,5-diamine 1,1-dioxide | |
0.026 | - |
in 100 mM triethanolamine, 10 mM EDTA, pH 7.4 and 10% of dimethyl sulfoxide, at 36°C | Trypanosoma cruzi | phenazine 5,9-dioxide | |
0.03 | 0.1 | in 100 mM triethanolamine, 10 mM EDTA, pH 7.4 and 10% of dimethyl sulfoxide, at 36°C | Trypanosoma cruzi | 6-[(E)-2-(5-nitrothiophen-2-yl)ethenyl]-2,1,3-benzoxadiazole 1-oxide | |
0.03 | 0.1 | in 100 mM triethanolamine, 10 mM EDTA, pH 7.4 and 10% of dimethyl sulfoxide, at 36°C | Trypanosoma cruzi | (2E)-N-[2-(3,4-dimethoxyphenyl)ethyl]-2-[(5-nitrofuran-2-yl)methylidene]hydrazinecarboxamide | |
0.03 | 0.1 | in 100 mM triethanolamine, 10 mM EDTA, pH 7.4 and 10% of dimethyl sulfoxide, at 36°C | Trypanosoma cruzi | 2,6-dibenzyl-4-[(5-nitrothiophen-2-yl)methylidene]-1,2,6-thiadiazinane-3,5-dione 1,1-dioxide | |
0.03 | 0.1 | in 100 mM triethanolamine, 10 mM EDTA, pH 7.4 and 10% of dimethyl sulfoxide, at 36°C | Trypanosoma cruzi | ethyl 3-phenyl-1,2,4-thiadiazole-5-carboxylate | |
0.1 | - |
IC50 about 0.1 mM, in 100 mM triethanolamine, 10 mM EDTA, pH 7.4 and 10% of dimethyl sulfoxide, at 36°C | Trypanosoma cruzi | 6-[(E)-2-[(4-fluorophenyl)sulfanyl]ethenyl]-2,1,3-benzoxadiazole 1-oxide | |
0.1 | - |
IC50 about 0.1 mM, in 100 mM triethanolamine, 10 mM EDTA, pH 7.4 and 10% of dimethyl sulfoxide, at 36°C | Trypanosoma cruzi | (2E)-2-[2-[(3-oxido-2,1,3-benzoxadiazol-5-yl)methoxy]benzylidene]-N-(prop-2-en-1-yl)hydrazinecarbothioamide | |
0.1 | - |
IC50 about 0.1 mM, in 100 mM triethanolamine, 10 mM EDTA, pH 7.4 and 10% of dimethyl sulfoxide, at 36°C | Trypanosoma cruzi | 4-(4-nitrobenzylidene)-2,6-bis(2-phenylethyl)-1,2,6-thiadiazinane-3,5-dione 1,1-dioxide | |
0.1 | - |
IC50 about 0.1 mM, in 100 mM triethanolamine, 10 mM EDTA, pH 7.4 and 10% of dimethyl sulfoxide, at 36°C | Trypanosoma cruzi | ethyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl)-1,2,4-thiadiazole-5-carboxylate | |
0.1 | - |
IC50 about 0.1 mM, in 100 mM triethanolamine, 10 mM EDTA, pH 7.4 and 10% of dimethyl sulfoxide, at 36°C | Trypanosoma cruzi | 3-(4-methylphenyl)-5-[(4-methylphenyl)sulfonyl]-1,2,4-thiadiazole | |
0.1 | - |
IC50 about 0.1 mM, in 100 mM triethanolamine, 10 mM EDTA, pH 7.4 and 10% of dimethyl sulfoxide, at 36°C | Trypanosoma cruzi | (2E)-N-(naphthalen-2-yl)-2-[(2E)-3-(5-nitrofuran-2-yl)prop-2-en-1-ylidene]hydrazinecarboxamide | |
0.1 | - |
IC50 about 0.1 mM, in 100 mM triethanolamine, 10 mM EDTA, pH 7.4 and 10% of dimethyl sulfoxide, at 36°C | Trypanosoma cruzi | (2E)-2-[(5-nitrofuran-2-yl)methylidene]hydrazinecarbothioamide | |
0.1 | - |
IC50 about 0.1 mM, in 100 mM triethanolamine, 10 mM EDTA, pH 7.4 and 10% of dimethyl sulfoxide, at 36°C | Trypanosoma cruzi | 4-[(5-nitrothiophen-2-yl)methylidene]-2,6-bis(2-phenylethyl)-1,2,6-thiadiazinane-3,5-dione 1,1-dioxide | |
0.1 | - |
IC50 about 0.1 mM, in 100 mM triethanolamine, 10 mM EDTA, pH 7.4 and 10% of dimethyl sulfoxide, at 36°C | Trypanosoma cruzi | 3,5-diphenyl-1,2,4-thiadiazole | |
0.1 | - |
IC50 about 0.1 mM, in 100 mM triethanolamine, 10 mM EDTA, pH 7.4 and 10% of dimethyl sulfoxide, at 36°C | Trypanosoma cruzi | 2-phenyl-4H-chromen-4-one | |
0.1 | - |
IC50 about 0.1 mM, in 100 mM triethanolamine, 10 mM EDTA, pH 7.4 and 10% of dimethyl sulfoxide, at 36°C | Trypanosoma cruzi | (2E)-2-[(4-methyl-5-oxido-1,2,5-oxadiazol-3-yl)methylidene]hydrazinecarbothioamide | |
0.1 | - |
IC50 about 0.1 mM, in 100 mM triethanolamine, 10 mM EDTA, pH 7.4 and 10% of dimethyl sulfoxide, at 36°C | Trypanosoma cruzi | N-[(2-oxido-4-phenyl-1,2,5-oxadiazol-3-yl)methyl]naphthalen-1-amine | |
0.1 | - |
IC50 about 0.1 mM, in 100 mM triethanolamine, 10 mM EDTA, pH 7.4 and 10% of dimethyl sulfoxide, at 36°C | Trypanosoma cruzi | 2-[(1E)-2-nitroprop-1-en-1-yl]thiophene | |
0.1 | - |
IC50 about 0.1 mM, in 100 mM triethanolamine, 10 mM EDTA, pH 7.4 and 10% of dimethyl sulfoxide, at 36°C | Trypanosoma cruzi | 5-[(1E)-2-nitroprop-1-en-1-yl]-1,3-benzodioxole | |
0.1 | - |
IC50 about 0.1 mM, in 100 mM triethanolamine, 10 mM EDTA, pH 7.4 and 10% of dimethyl sulfoxide, at 36°C | Trypanosoma cruzi | (1Z,2Z)-N,N'-dihydroxy-4-methylcyclohexa-3,5-diene-1,2-diimine | |
0.1 | - |
IC50 about 0.1 mM, in 100 mM triethanolamine, 10 mM EDTA, pH 7.4 and 10% of dimethyl sulfoxide, at 36°C | Trypanosoma cruzi | 3-nitrobiphenyl-4-amine | |
0.4 | - |
in 100 mM triethanolamine, 10 mM EDTA, pH 7.4 and 10% of dimethyl sulfoxide, at 36°C | Trypanosoma cruzi | 8-bromo-5,10-dioxidophenazin-2-yl chloroacetate |