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Literature summary for 5.2.1.8 extracted from

  • Lim, Y.S.; Tran, H.T.; Park, S.J.; Yim, S.A.; Hwang, S.B.
    Peptidyl-prolyl isomerase Pin1 is a cellular factor required for hepatitis C virus propagation (2011), J. Virol., 85, 8777-8888.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 5.2.1.8

Cloned(Commentary)

Cloned (Comment) Organism
-
 Homo sapiens

Protein Variants

Protein Variants Comment Organism
C113A isomerase-inactive Homo sapiens
S16A isomerase-inactive Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
juglone i.e. 5-hydroxy-1,4-naphthoquinone, natural inhibitor of Pin1 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Homo sapiens

Synonyms

Synonyms Comment Organism
Peptidyl-prolyl cis-trans isomerase
-
 Homo sapiens
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1
-
 Homo sapiens
Pin1
-
 Homo sapiens
PPIase
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens Pin1 expression is increased by NS5B protein up

General Information

General Information Comment Organism
malfunction silencing of Pin1 expression results in decrease of hepatitis C virus replication in both hepatitis C virus replicon cells and cell culture grown hepatitis C virus-infected cells Homo sapiens
physiological function Pin1 is a host factor for hepatitis C virus propagation and may contribute to hepatitis C virus-induced liver pathogenesis. Both binding and isomerase activities of Pin1 are essential for hepatitis C virus replication Homo sapiens