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Literature summary for 5.2.1.8 extracted from

  • Liu, Z.; Yang, F.; Robotham, J.M.; Tang, H.
    Critical role of cyclophilin A and its prolyl-peptidyl isomerase activity in the structure and function of the hepatitis C virus replication complex (2009), J. Virol., 83, 6554-6565.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 5.2.1.8

Protein Variants

Protein Variants Comment Organism
additional information introduction of point mutations in the prolyl-peptidyl isomerase motif of CyPA. Downregulation of host CyPA by RNA interference, and mutations in viral NS5B, that confers cyclosporine-resistant binding to CyPA, contribute to the cyclosporine resistance of the replicons harboring these mutations Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
cyclosporin A forms an inhibitory complex with cyclophilin. CyPA is a major intracellular target of cyclosporines Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens incorporation of the HCV polymerase into the replication complex depends on its interaction with a cellular chaperone protein, cyclosporine inhibits HCV replication by blocking this critical interaction and the PPIase activity of CyPA, modeling of the pathway, overview. CyPA is associated with CRC-incorporated HCV replicase in a cyclosporine-sensitive manner ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
Huh-7.5 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information incorporation of the HCV polymerase into the replication complex depends on its interaction with a cellular chaperone protein, cyclosporine inhibits HCV replication by blocking this critical interaction and the PPIase activity of CyPA, modeling of the pathway, overview. CyPA is associated with CRC-incorporated HCV replicase in a cyclosporine-sensitive manner Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
Cyclophilin A
-
 Homo sapiens
CyPA
-
 Homo sapiens
More the enzyme belongs to the CyP family of proteins Homo sapiens
prolyl-peptidyl isomerase
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function cyclophilin A is an essential cofactor for hepatitis C virus infection and the intracellular target of cyclosporine’s anti-HCV effect, mechanism by which CyPA facilitates HCV replication, overview Homo sapiens