Application | Comment | Organism |
---|---|---|
pharmacology | Pin1 is a therapeutic target for reducing aberrant phosphorylation of NF proteins in neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
expression of GST-tagged Pin1 | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
A16S | site-directed mutagenesis, dominant-negative Pin1 point mutation | Homo sapiens |
additional information | silencing of Pin1 by siRNA, Pin1 siRNA-transfected neurons show the reduction in perikaryal phosphorylation of NF, siRNA inhibits okadaic acid-induced perikaryal phosphorylation of NF-M/H, immunohistochemic analysis, overview | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | inhibition of Pin1 inhibits okadaic acid-induced aberrant perikaryal phosphorylation of NF, and inhibition of Pin1 inhibits the okadaic acid- or Fos-induced neuronal apoptosis | Homo sapiens | |
additional information | inhibition of Pin1 inhibits okadaic acid-induced aberrant perikaryal phosphorylation of NF, and inhibition of Pin1 inhibits the okadaic acid- or Fos-induced neuronal apoptosis | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Rattus norvegicus | prolyl isomerase Pin1 recognizes and induces cis-trans isomerization of pSer/Thr-Pro bonds, conferring phosphorylation-dependent conformational changes relevant for protein function. Pin1 can directly modulate the NF dephosphorylation mediated by PP2A, independent of JNK, extracellular signal-regulated kinase, and Cdk5 pathways | ? | - |
? | |
additional information | Homo sapiens | prolyl isomerase Pin1 recognizes and induces cis-trans isomerization of pSer/Thr-Pro bonds, conferring phosphorylationdependent conformational changes relevant for protein function. Pin1 can directly modulate the NF dephosphorylation mediated by PP2A, independent of JNK, extracellular signal-regulated kinase, and Cdk5 pathways | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Rattus norvegicus | - |
Sprague-Dawley rats | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Homo sapiens | - |
brain | - |
Rattus norvegicus | - |
embryo | - |
Rattus norvegicus | - |
neuron | cortical | Homo sapiens | - |
neuron | primary cortical, Pin1 is present in both axons and cell bodies | Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | prolyl isomerase Pin1 recognizes and induces cis-trans isomerization of pSer/Thr-Pro bonds, conferring phosphorylation-dependent conformational changes relevant for protein function. Pin1 can directly modulate the NF dephosphorylation mediated by PP2A, independent of JNK, extracellular signal-regulated kinase, and Cdk5 pathways | Rattus norvegicus | ? | - |
? | |
additional information | prolyl isomerase Pin1 recognizes and induces cis-trans isomerization of pSer/Thr-Pro bonds, conferring phosphorylationdependent conformational changes relevant for protein function. Pin1 can directly modulate the NF dephosphorylation mediated by PP2A, independent of JNK, extracellular signal-regulated kinase, and Cdk5 pathways | Homo sapiens | ? | - |
? | |
additional information | Pin1 inhibits the dephosphorylation of NF by PP2A in vitro | Homo sapiens | ? | - |
? | |
additional information | Pin1 inhibits the dephosphorylation of NF by PP2A in vitro | Rattus norvegicus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
peptidyl-prolyl isomerase 1 | - |
Homo sapiens |
peptidyl-prolyl isomerase 1 | - |
Rattus norvegicus |
Pin1 | - |
Homo sapiens |
Pin1 | - |
Rattus norvegicus |
General Information | Comment | Organism |
---|---|---|
physiological function | Pin1 recognizes and induces cis-trans isomerization of pSer/Thr-Pro bonds, conferring phosphorylation-dependent conformational changes relevant for protein function. In cortical neurons, Pin1 modulates the topographic phosphorylation of the proline-directed Ser/Thr residues within the tail domain of NF proteins by inhibiting the dephosphorylation by PP2A. Inhibition of Pin1 inhibits okadaic acid-induced aberrant perikaryal phosphorylation of NF, and inhibition of Pin1 inhibits the okadaic acid- or Fos-induced neuronal apoptosis, signaling role of PP2A by Pin1, overview | Rattus norvegicus |
physiological function | Pin1 recognizes and induces cis-trans isomerization of pSer/Thr-Pro bonds, conferring phosphorylationdependent conformational changes relevant for protein function. In cortical neurons, Pin1 modulates the topographic phosphorylation of the proline-directed Ser/Thr residues within the tail domain of NF proteins by inhibiting the dephosphorylation by PP2A. Inhibition of Pin1 inhibits okadaic acid-induced aberrant perikaryal phosphorylation of NF, and inhibition of Pin1 inhibits the okadaic acid- or Fos-induced neuronal apoptosis, signaling role of PP2A by Pin1, overview | Homo sapiens |