Protein Variants | Comment | Organism |
---|---|---|
additional information | both hydrogen peroxide and heat stresses induce phosphorylation of neurofilament protein NF-H in transfected HEK-293 cells and primary cortical cultures. Knockdown of Pin1 by transfected Pin1 short interference RNA and dominant negative-Pin1 rescues the effect of stress-induced NF-H phosphorylation | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q13526 | isoform Pin1 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
cell culture | primary cortical culture | Homo sapiens | - |
HEK-293 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | isoform Pin1 modulates oxidative stress-induced neurofilament NF-H phosphorylation. In vitro, the addition of Pin1 substantially increases phosphorylation of NF-H KSP repeats by proline-directed kinases, Erk1/2, Cdk5/p35, and JNK3 in a concentration-dependent manner. In vivo, dominant-negative Pin1 and Pin1 small interfering RNA inhibit epidermal growth factor-induced NF-H phosphorylation | Homo sapiens | ? | - |
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