Literature summary for 5.2.1.8 extracted from

Zheng, J.; Koblinski, J.E.; Dutson, L.V.; Feeney, Y.B.; Clevenger, C.V.
Prolyl isomerase cyclophilin A regulation of Janus-activated kinase 2 and the progression of human breast cancer (2008), Cancer Res., 68, 7769-7778.

Search for more literature for 5.2.1.8

Application

Application	Comment	Organism
medicine	isoform CypA is necessary for the prolactin-induced activation of Janus-activated kinase 2 and the progression of human breast cancer. Direct correlation between the levels of activity of CypA and the extent of prolactin-induced signaling and gene expression. A CypA-mediated conformational change withi the prolactin r/Janus-activated kinase 2 complex is required for prolactin-induced transduction and function	Homo sapiens

Cloned(Commentary)

Cloned (Comment)	Organism
expression in T47D cell, MCF-7 cell, MDA-231 cell	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	isoform CypA is necessary for the prolactin-induced activation of Janus-activated kinase 2 and the progression of human breast cancer	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
MCF-7 cell	-	Homo sapiens	-
MDA-MB-231 cell	-	Homo sapiens	-
T-47D cell	-	Homo sapiens	-

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Release 2023.1 (January 2023)