Cloned (Comment) | Organism |
---|---|
expression in Escherichia coli | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
P16S | 10fold decrease in ratio kcat/Km at 10°C. Mutant is extremely sensitive to guanidinium-HCl and shows increased susceptibility to urea. Folding time of the mutant is extended | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
cyclosporin A | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
isoform cyclophilin A | - |
Purification (Comment) | Organism |
---|---|
recombinant enzyme and mutant P16S | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
N-succinyl-Ala-Ala-(trans)-Pro-Phe-4-nitroanilide | - |
Homo sapiens | N-succinyl-Ala-Ala-(cis)-Pro-Phe-4-nitroanilide | - |
? |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00000265 | - |
- |
Homo sapiens | cyclosporin A |