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Literature summary for 5.2.1.8 extracted from

  • Reimer, T.; Weiwad, M.; Schierhorn, A.; Ruecknagel, P.K.; Rahfeld, J.U.; Bayer, P.; Fischer, G.
    Phosphorylation of the N-terminal domain regulates subcellular localization and DNA binding properties of the peptidyl-prolyl cis/trans isomerase hPar14 (2003), J. Mol. Biol., 330, 955-966.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
S19A mutation abolishes phosphorylation and alters the subcellular localization from predominantly nuclear to significantly cytoplasmic Homo sapiens
S19E mutant enzyme is localized around the nuclear envelope, but does not penetrate into the nucleoplasm, in vitro DNA-binding affinity is strongly reduced Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus bound to double-stranded DNA. The subcellular localization is regulated by posttranslational modification of its N-terminal domain Homo sapiens 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens folding helper enzyme that plays a role in cell-cycle and chromatin remodeling ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein phosphorylated at Ser19 in vivo and in vitro. In human HeLa cells the protein is most likely modified by casein kinase 2 Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information folding helper enzyme that plays a role in cell-cycle and chromatin remodeling Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
h Par14
-
Homo sapiens
parvulin1 4
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Homo sapiens