Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 5.2.1.8 extracted from

  • Zhang, Y.; Fuessel, S.; Reimer, U.; Schutkowski, M.; Fischer, G.
    Substrate-based design of reversible Pin1 inhibitors (2002), Biochemistry, 41, 11868-11877.
    View publication on PubMed
Search for more literature for 5.2.1.8

Inhibitors

Inhibitors Comment Organism Structure
acetyl-Ala-Ala-D-Ser(PO3H2)-Pro-Leu-NH-4-nitroanilide IC50: 0.001 mM Homo sapiens
acetyl-Ala-Ala-D-Ser-Pro-Leu-NH-4-nitroanilide IC50: 0.085 mM Homo sapiens
Ala-Pro
-
 Homo sapiens
D-Ser(PO3H2)-Pro 1 mM, 20% inhibition Homo sapiens
Phe-Ser(PO3H2)-PSI[CS-N]-Pro-Phe-NH-4-nitroanilide IC50: 0.004 mM Homo sapiens
Phe-Ser-PSI[CS-N]-Pro-Phe-NH-4-nitroanilide IC50: 0.097 mM Homo sapiens
Ser(PO3H2)-Pro IC50: 2.0 mM Homo sapiens
Ser-Pro
-
 Homo sapiens
Ser-PSI[CS-N]-Pro
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens enzyme is required for cell cycle progression ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-Ala-Ala-(cis)-Pro-Ala-Lys-NH2
-
 Homo sapiens acetyl-Ala-Ala-(trans)-Pro-Ala-Lys-NH2
-
 ?
acetyl-Ala-Ala-Ser(PO3H2)-(cis)-Pro-Arg-NH-4-nitroanilide
-
 Homo sapiens acetyl-Ala-Ala-Ser(PO3H2)-(trans)-Pro-Arg-NH-4-nitroanilide
-
 ?
Ala-Ala-(cis)-Pro-Ala
-
 Homo sapiens Ala-Ala-(trans)-Pro-Ala
-
 ?
Ala-Ser(PO3H2)-(cis)-Pro
-
 Homo sapiens Ala-Ser(PO3H2)-(trans)-Pro
-
 ?
Ala-Ser(PO3H2)-(cis)-Pro-Arg
-
 Homo sapiens Ala-Ser(PO3H2)-(trans)-Pro-Arg
-
 ?
additional information no catalysis is observed with the substrates Ala-(cis)-Pro, Ala-Ala-(cis)-Pro, Ala-(cis)-Pro-Ala, Ser-(cis)-Pro and Ser(PO3H2)-(cis)-Pro Homo sapiens ?
-
 ?
additional information enzyme is required for cell cycle progression Homo sapiens ?
-
 ?
Ser(PO3H2)-(cis)-Pro-Arg
-
 Homo sapiens Ser(PO3H2)-(trans)-Pro-Arg
-
 ?
Ser(PO3H2)-(cis)-Pro-Arg-NH-4-nitroanilide
-
 Homo sapiens Ser(PO3H2)-(trans)-Pro-Arg-NH-4-nitroanilide
-
 ?
succinyl-Ala-(cis)-Pro-Phe-NH-4-nitroanilide
-
 Homo sapiens succinyl-Ala-(trans)-Pro-Phe-NH-4-nitroanilide
-
 ?
succinyl-Ala-Ala-(cis)-Pro-Phe-NH-4-nitroanilide
-
 Homo sapiens succinyl-Ala-Ala-(trans)-Pro-Phe-NH-4-nitroanilide
-
 ?

Synonyms

Synonyms Comment Organism
Pin1
-
 Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1
-
 Ser(PO3H2)-Pro
-
 Homo sapiens
19
-
 Ala-Pro
-
 Homo sapiens
27
-
 Ser-Pro
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.001
-
 IC50: 0.001 mM Homo sapiens acetyl-Ala-Ala-D-Ser(PO3H2)-Pro-Leu-NH-4-nitroanilide
0.004
-
 IC50: 0.004 mM Homo sapiens Phe-Ser(PO3H2)-PSI[CS-N]-Pro-Phe-NH-4-nitroanilide
0.085
-
 IC50: 0.085 mM Homo sapiens acetyl-Ala-Ala-D-Ser-Pro-Leu-NH-4-nitroanilide
0.097
-
 IC50: 0.097 mM Homo sapiens Phe-Ser-PSI[CS-N]-Pro-Phe-NH-4-nitroanilide
2
-
 IC50: 2.0 mM Homo sapiens Ser(PO3H2)-Pro