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Literature summary for 5.1.99.4 extracted from

  • Schmitz, W.; Albers, C.; Fingerhut, R.; Conzelmann, E.
    Purification and characterization of an alpha-methylacyl-CoA racemase from human liver (1995), Eur. J. Biochem., 231, 815-822.
    View publication on PubMed

Application

Application Comment Organism
medicine the activity of EC 5.1.99.4 may prove to be a valuable parameter for the prenatal diagnosis of general defects of peroxisome biogenesis such as Zellweger syndrome Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
2-(4-Isobutylphenyl)propionic acid
-
Homo sapiens
2-(4-Isobutylphenyl)propionic acid
-
Rattus norvegicus
2-methylmyristoyl-CoA
-
Homo sapiens
2-methylmyristoyl-CoA
-
Rattus norvegicus
2-methyloctanoyl-CoA
-
Homo sapiens
2-methyloctanoyl-CoA
-
Rattus norvegicus
palmitoyl-CoA inhibition is caused by the formation of stable mixed micelles Homo sapiens
palmitoyl-CoA
-
Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0316
-
trihydroxycoprostanoyl-CoA
-
Homo sapiens
0.172
-
pristanoyl-CoA
-
Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion co-distributed exclusively with mitochondrial marker enzymes Rattus norvegicus 5739
-
mitochondrion only 10-30% of the activity is found in mitochondria Homo sapiens 5739
-
peroxisome bulk activity Rattus norvegicus 5777
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
47100
-
1 * 47100, SDS-PAGE Homo sapiens
47700
-
gel filtration Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
chorionic villus
-
Homo sapiens
-
fibroblast
-
Homo sapiens
-
Hep-G2 cell
-
Homo sapiens
-
liver
-
Homo sapiens
-
liver
-
Rattus norvegicus
-
skin fibroblast
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(S)-2-Methyltetradecanoyl-CoA r Homo sapiens (R)-2-Methyltetradecanoyl-CoA
-
?
(S)-Pristanoyl-CoA
-
Homo sapiens (R)-Pristanoyl-CoA
-
?
(S)-Pristanoyl-CoA r Rattus norvegicus (R)-Pristanoyl-CoA
-
?
(S)-Trihydroxycoprostanoyl-CoA
-
Homo sapiens (R)-Trihydroxycoprostanoyl-CoA
-
?
(S)-Trihydroxycoprostanoyl-CoA
-
Rattus norvegicus (R)-Trihydroxycoprostanoyl-CoA
-
?
additional information
-
Rattus norvegicus ?
-
?
additional information no activity with free fatty acids Homo sapiens ?
-
?
pristanoyl-CoA
-
Homo sapiens ?
-
?

Subunits

Subunits Comment Organism
monomer
-
Rattus norvegicus
monomer 1 * 47100, SDS-PAGE Homo sapiens

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
35 40 slow loss of activity Homo sapiens
50
-
half-life: 15 min Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
-
Homo sapiens

pH Range

pH Minimum pH Maximum Comment Organism
6.5 9 more than 80% of maximal activity between pH 6.5 and pH 9.0, inactive below pH 5 Homo sapiens