Application | Comment | Organism |
---|---|---|
medicine | the activity of EC 5.1.99.4 may prove to be a valuable parameter for the prenatal diagnosis of general defects of peroxisome biogenesis such as Zellweger syndrome | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-(4-Isobutylphenyl)propionic acid | - |
Homo sapiens | |
2-(4-Isobutylphenyl)propionic acid | - |
Rattus norvegicus | |
2-methylmyristoyl-CoA | - |
Homo sapiens | |
2-methylmyristoyl-CoA | - |
Rattus norvegicus | |
2-methyloctanoyl-CoA | - |
Homo sapiens | |
2-methyloctanoyl-CoA | - |
Rattus norvegicus | |
palmitoyl-CoA | inhibition is caused by the formation of stable mixed micelles | Homo sapiens | |
palmitoyl-CoA | - |
Rattus norvegicus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0316 | - |
trihydroxycoprostanoyl-CoA | - |
Homo sapiens | |
0.172 | - |
pristanoyl-CoA | - |
Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | co-distributed exclusively with mitochondrial marker enzymes | Rattus norvegicus | 5739 | - |
mitochondrion | only 10-30% of the activity is found in mitochondria | Homo sapiens | 5739 | - |
peroxisome | bulk activity | Rattus norvegicus | 5777 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
47100 | - |
1 * 47100, SDS-PAGE | Homo sapiens |
47700 | - |
gel filtration | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
chorionic villus | - |
Homo sapiens | - |
fibroblast | - |
Homo sapiens | - |
Hep-G2 cell | - |
Homo sapiens | - |
liver | - |
Homo sapiens | - |
liver | - |
Rattus norvegicus | - |
skin fibroblast | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(S)-2-Methyltetradecanoyl-CoA | r | Homo sapiens | (R)-2-Methyltetradecanoyl-CoA | - |
? | |
(S)-Pristanoyl-CoA | - |
Homo sapiens | (R)-Pristanoyl-CoA | - |
? | |
(S)-Pristanoyl-CoA | r | Rattus norvegicus | (R)-Pristanoyl-CoA | - |
? | |
(S)-Trihydroxycoprostanoyl-CoA | - |
Homo sapiens | (R)-Trihydroxycoprostanoyl-CoA | - |
? | |
(S)-Trihydroxycoprostanoyl-CoA | - |
Rattus norvegicus | (R)-Trihydroxycoprostanoyl-CoA | - |
? | |
additional information | - |
Rattus norvegicus | ? | - |
? | |
additional information | no activity with free fatty acids | Homo sapiens | ? | - |
? | |
pristanoyl-CoA | - |
Homo sapiens | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
monomer | - |
Rattus norvegicus |
monomer | 1 * 47100, SDS-PAGE | Homo sapiens |
Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|
35 | 40 | slow loss of activity | Homo sapiens |
50 | - |
half-life: 15 min | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8 | - |
- |
Homo sapiens |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
6.5 | 9 | more than 80% of maximal activity between pH 6.5 and pH 9.0, inactive below pH 5 | Homo sapiens |