Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 5.1.3.2 extracted from

  • Schulz, J.M.; Ross, K.L.; Malmstrom, K.; Krieger, M.; Fridovich-Keil, J.L.
    Mediators of galactose sensitivity in UDP-galactose 4'-epimerase-impaired mammalian cells (2005), J. Biol. Chem., 280, 13493-13502.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression in GALE-null line of Chineses hamster ovary cells. GALE-null cells accumulats abnormally high levels of Hal-1-P and UDP-Gal and abnormally low levels of UDP-Glc and UDP-GLcNAc in the presence of galactose. Human GALE expression corrects each of theses defects Homo sapiens
expression in GALE-null line of Chinesese hamster ovary cells. Enzyme from Escherichia coli can not restore the metabolic balance, because unlike the mammalian enzyme it can not catalyze the interconversion of UDP-GalNAc and UDP-GlcNAc Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
UDP-galactose Escherichia coli enzyme catalyzes the first step of the Lelpoir pathway UDP-glucose
-
r
UDP-galactose Homo sapiens enzyme contributes to the Lelpoir pathway and also functions as a gatekeeper overseeing the ratios of important substrate pools required for the synthesis of glycosylated macromolecules UDP-glucose
-
r
UDP-GalNAc Homo sapiens enzyme contributes to the Lelpoir pathway and also functions as a gatekeeper overseeing the ratios of important substrate pools required for the synthesis of glycosylated macromolecules UDP-GlcNAc
-
r

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information no interconversion of UDP-GalNAc and UDP-GlcNAc Escherichia coli ?
-
?
UDP-galactose
-
Escherichia coli UDP-glucose
-
r
UDP-galactose
-
Homo sapiens UDP-glucose
-
r
UDP-galactose enzyme catalyzes the first step of the Lelpoir pathway Escherichia coli UDP-glucose
-
r
UDP-galactose enzyme contributes to the Lelpoir pathway and also functions as a gatekeeper overseeing the ratios of important substrate pools required for the synthesis of glycosylated macromolecules Homo sapiens UDP-glucose
-
r
UDP-GalNAc
-
Homo sapiens UDP-GlcNAc
-
r
UDP-GalNAc enzyme contributes to the Lelpoir pathway and also functions as a gatekeeper overseeing the ratios of important substrate pools required for the synthesis of glycosylated macromolecules Homo sapiens UDP-GlcNAc
-
r

Synonyms

Synonyms Comment Organism
GalE
-
Escherichia coli
GalE
-
Homo sapiens
UDP-galactose 4'-epimerase
-
Escherichia coli
UDP-galactose 4'-epimerase
-
Homo sapiens