Protein Variants | Comment | Organism |
---|---|---|
Y299C | mutation results in a loss of epimerase activity with regard to UDPgalactose by almost 5fold, it results in a gain of activity against UDP-GalNAc by more than 230fold | Escherichia coli |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | impairement of the enzyme results in galacosemia III that can lead to symptoms ranging from benign to severe | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
- |
- |
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | impairement of the enzyme results in galacosemia III that can lead to symptoms ranging from benign to severe | Homo sapiens | ? | - |
? | |
UDP-GlcNAc | - |
Homo sapiens | UDP-GalNAc | - |
r | |
UDP-GlcNAc | wild-type enzyme shows no interconversion of UDP-GlcNAc and UDP-GalNAc, mutation Y299C results in a gain of activity against UDP-GalNAc by more than 230fold | Escherichia coli | UDP-GalNAc | - |
r |