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Literature summary for 5.1.1.3 extracted from

  • Pal, M.; Bearne, S.L.
    Inhibition of glutamate racemase by substrate-product analogues (2014), Bioorg. Med. Chem. Lett., 24, 1432-1436.
    View publication on PubMed
Search for more literature for 5.1.1.3

Inhibitors

Inhibitors Comment Organism Structure
(R,S)-1-hydroxy-1-oxo-4-amino-4-carboxyphosphorinane
-
 Enterococcus faecalis
(R,S)-4-amino-4-carboxy-1,1-dioxotetrahydro-thiopyran
-
 Enterococcus faecalis
1,1-dioxo-tetrahydrothiopyran-4-one
-
 Enterococcus faecalis
1-hydroxyphosphinan-4-one 1-oxide
-
 Enterococcus faecalis
2-amino-4-phosphonobutanoic acid
-
 Enterococcus faecalis
bis(2-carboxyethyl)-phosphinic acid
-
 Enterococcus faecalis
additional information substrate-product analogue inhibitor synthesis and evaluation, overview Enterococcus faecalis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-glutamate Enterococcus faecalis
-
 D-glutamate
-
 r

Organism

Organism UniProt Comment Textmining
Enterococcus faecalis
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-glutamate
-
 Enterococcus faecalis D-glutamate
-
 r

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.1
-
 (R,S)-1-hydroxy-1-oxo-4-amino-4-carboxyphosphorinane pH and temperature not specified in the publication Enterococcus faecalis
18.4
-
 1,1-dioxo-tetrahydrothiopyran-4-one pH and temperature not specified in the publication Enterococcus faecalis

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
21.2
-
 pH and temperature not specified in the publication Enterococcus faecalis 1,1-dioxo-tetrahydrothiopyran-4-one
24.1
-
 pH and temperature not specified in the publication Enterococcus faecalis (R,S)-1-hydroxy-1-oxo-4-amino-4-carboxyphosphorinane
47.7
-
 pH and temperature not specified in the publication Enterococcus faecalis 1-hydroxyphosphinan-4-one 1-oxide
60.4
-
 pH and temperature not specified in the publication Enterococcus faecalis bis(2-carboxyethyl)-phosphinic acid
105
-
 pH and temperature not specified in the publication Enterococcus faecalis 2-amino-4-phosphonobutanoic acid
215
-
 pH and temperature not specified in the publication Enterococcus faecalis (R,S)-4-amino-4-carboxy-1,1-dioxotetrahydro-thiopyran

General Information

General Information Comment Organism
physiological function D-glutamate is an essential biosynthetic building block of the peptidoglycans that encapsulate the bacterial cell wall Enterococcus faecalis