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Literature summary for 5.1.1.1 extracted from

  • Awasthy, D.; Bharath, S.; Subbulakshmi, V.; Sharma, U.
    Alanine racemase mutants of Mycobacterium tuberculosis require D-alanine for growth and are defective for survival in macrophages and mice (2012), Microbiology, 158, 319-327.
    View publication on PubMed
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Application

Application Comment Organism
pharmacology Alr of Mycobacterium tuberculosis is a valid drug target and inhibition of Alr alone results in loss of viability in vitro and in vivo Mycobacterium tuberculosis

Inhibitors

Inhibitors Comment Organism Structure
D-cycloserine specific inhibition is reversible by D-alanine in the growth medium Mycobacterium tuberculosis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-alanine Mycobacterium tuberculosis
-
 D-alanine
-
 r
L-alanine Mycobacterium tuberculosis H37Rv
-
 D-alanine
-
 r

Organism

Organism UniProt Comment Textmining
Mycobacterium tuberculosis P9WQA9
-
-
Mycobacterium tuberculosis H37Rv P9WQA9
-
-

Source Tissue

Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-alanine
-
 Mycobacterium tuberculosis D-alanine
-
 r
L-alanine
-
 Mycobacterium tuberculosis H37Rv D-alanine
-
 r

Synonyms

Synonyms Comment Organism
ALR
-
 Mycobacterium tuberculosis

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate dependent on Mycobacterium tuberculosis

General Information

General Information Comment Organism
malfunction depletion of D-alanine results in rapid loss of viability. The alr mutant is defective for growth in macrophages Mycobacterium tuberculosis
physiological function the enzyme is essential for the organism, it is not possible to generate an alr knockout mutant in the absence of a complementing gene copy or D-alanine in the growth medium Mycobacterium tuberculosis