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Literature summary for 5.1.1.1 extracted from

  • Zajdowicz, S.L.; Jones-Carson, J.; Vazquez-Torres, A.; Jobling, M.G.; Gill, R.E.; Holmes, R.K.
    Alanine racemase mutants of Burkholderia pseudomallei and Burkholderia mallei and use of alanine racemase as a non-antibiotic-based selectable marker (2011), PLoS ONE, 6, e21523.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli strain ALA1 Burkholderia mallei
expressed in Escherichia coli strain ALA1 Burkholderia pseudomallei

Organism

Organism UniProt Comment Textmining
Burkholderia mallei Q62JA4
-
-
Burkholderia mallei ATCC 23344 Q62JA4
-
-
Burkholderia pseudomallei Q63ME6 alanine racemase isoform 2
-
Burkholderia pseudomallei Q63SZ2 alanine racemase isoform 1
-
Burkholderia pseudomallei K96243 Q63ME6 alanine racemase isoform 2
-
Burkholderia pseudomallei K96243 Q63SZ2 alanine racemase isoform 1
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-alanine
-
Burkholderia mallei D-alanine
-
?
L-alanine
-
Burkholderia pseudomallei D-alanine
-
?
L-alanine
-
Burkholderia mallei ATCC 23344 D-alanine
-
?
L-alanine
-
Burkholderia pseudomallei K96243 D-alanine
-
?

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate
-
Burkholderia mallei
pyridoxal 5'-phosphate
-
Burkholderia pseudomallei

General Information

General Information Comment Organism
malfunction during log phase growth without D-alanine, the viable counts of alanine racemase-deficient mutants of Burkholderia pseudomallei decrease within 2 h by about 1000fold, and no viable bacteria are present at 24 h. The alanine racemase-deficient mutant of Burkholderia pseudomallei K96243 exhibits attenuation versus its isogenic parental strain with respect to growth and survival in murine peritoneal macrophages Burkholderia pseudomallei
malfunction during log phase growth without D-alanine, the viable counts of alanine racemase-deficient mutants of Burkholderia pseudomallei decrease within 2 h by about 10fold, and no viable bacteria are present at 24 h Burkholderia mallei