Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli as an N-terminal polyhistidine fusion | Mycobacterium tuberculosis |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(4R)-4-amino-3-isoxazolidinone | - |
Mycobacterium tuberculosis | |
1,1'-(2-oxido-1,2,5-oxadiazole-3,4-diyl)-bis (1-(2-thienyl))-methanone | - |
Mycobacterium tuberculosis | |
1-amino-cyclopropane phosphonate | - |
Mycobacterium tuberculosis | |
2-(2-hydroxyphenoxy)-N-methylacetamide | - |
Mycobacterium tuberculosis | |
2-(4,6-dimethyl-3-oxo-[1,2]thiazolo[5,4-b]pyridin-2-yl)-N-[2-(4-ethoxyphenyl)ethyl]acetamide | - |
Mycobacterium tuberculosis | |
2-(4-methoxyphenyl)-1-morpholin-4-ylethanethione | - |
Mycobacterium tuberculosis | |
2-(4-methylphenyl)-1-morpholin-4-ylethanethione | - |
Mycobacterium tuberculosis | |
2-(hydoxyimino)-6-methyl-2H-benzopyran-3-carboxamide | - |
Mycobacterium tuberculosis | |
2-(pyridin-3-ylcarbamothioyl sulfanyl)acetic acid | - |
Mycobacterium tuberculosis | |
2-N',2-N',7-N',7-N'-tetramethyl-9H-fluorene-2,7-disulfonohydrazide | - |
Mycobacterium tuberculosis | |
2-phenyl-1-piperidin-1-ylethanethione | - |
Mycobacterium tuberculosis | |
3,3-dihydroxy-1H-quinoline-2,4-dione | - |
Mycobacterium tuberculosis | |
5-chloro-N-(3-chloro-4-methoxyphenyl)-2-(methylsulfonyl)pyrimidine-4-carboxamide | - |
Mycobacterium tuberculosis | |
6-O-[3-chloro-4-(6-methoxycarbonylpyridine-2-carbonyl)oxyphenyl] 2-O-methyl pyridine-2,6-dicarboxylate | - |
Mycobacterium tuberculosis | |
alanine | - |
Mycobacterium tuberculosis | |
alanine phosphonate | - |
Mycobacterium tuberculosis | |
beta,beta,beta-trifluoroalanine | - |
Mycobacterium tuberculosis | |
beta-chloroalanine | - |
Mycobacterium tuberculosis | |
beta-fluoroalanine | - |
Mycobacterium tuberculosis | |
chloro-vinyl glycine | - |
Mycobacterium tuberculosis | |
D-cycloserine | - |
Mycobacterium tuberculosis | |
ethyl 3-(pyridin-2-ylthio)propanoate | - |
Mycobacterium tuberculosis | |
fluoro-alanine | - |
Mycobacterium tuberculosis | |
fluoro-vinyl glycine | - |
Mycobacterium tuberculosis | |
L-alanine phosphonic acid | - |
Mycobacterium tuberculosis | |
N',N',4-trimethylbenzenesulfonohydrazide | - |
Mycobacterium tuberculosis | |
N-benzyl-5-chloro-2-methylsulfonylpyrimidine-4-carboxamide | - |
Mycobacterium tuberculosis | |
N-hydroxy-2-(2-hydroxyphenoxy)acetamide | - |
Mycobacterium tuberculosis | |
O-carbamoyl-D-serine | - |
Mycobacterium tuberculosis |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mycobacterium tuberculosis | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Mycobacterium tuberculosis |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-alanine | - |
Mycobacterium tuberculosis | L-alanine | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ALR | - |
Mycobacterium tuberculosis |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
pyridoxal 5'-phosphate | - |
Mycobacterium tuberculosis |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.02 | - |
3,3-dihydroxy-1H-quinoline-2,4-dione | in 100 mM Tris-Tricine, pH 8.5, temperature not specified in the publication | Mycobacterium tuberculosis | |
0.038 | - |
ethyl 3-(pyridin-2-ylthio)propanoate | in 100 mM Tris-Tricine, pH 8.5, temperature not specified in the publication | Mycobacterium tuberculosis | |
0.08 | - |
2-phenyl-1-piperidin-1-ylethanethione | in 100 mM Tris-Tricine, pH 8.5, temperature not specified in the publication | Mycobacterium tuberculosis | |
0.086 | - |
(4R)-4-amino-3-isoxazolidinone | in 100 mM Tris-Tricine, pH 8.5, temperature not specified in the publication | Mycobacterium tuberculosis | |
0.63 | - |
N-benzyl-5-chloro-2-methylsulfonylpyrimidine-4-carboxamide | in 100 mM Tris-Tricine, pH 8.5, temperature not specified in the publication | Mycobacterium tuberculosis | |
0.68 | - |
6-O-[3-chloro-4-(6-methoxycarbonylpyridine-2-carbonyl)oxyphenyl] 2-O-methyl pyridine-2,6-dicarboxylate | in 100 mM Tris-Tricine, pH 8.5, temperature not specified in the publication | Mycobacterium tuberculosis | |
0.76 | - |
5-chloro-N-(3-chloro-4-methoxyphenyl)-2-(methylsulfonyl)pyrimidine-4-carboxamide | in 100 mM Tris-Tricine, pH 8.5, temperature not specified in the publication | Mycobacterium tuberculosis | |
0.93 | - |
2-(4,6-dimethyl-3-oxo-[1,2]thiazolo[5,4-b]pyridin-2-yl)-N-[2-(4-ethoxyphenyl)ethyl]acetamide | in 100 mM Tris-Tricine, pH 8.5, temperature not specified in the publication | Mycobacterium tuberculosis |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.001 | - |
in 100 mM Tris-Tricine, pH 8.5, temperature not specified in the publication | Mycobacterium tuberculosis | 6-O-[3-chloro-4-(6-methoxycarbonylpyridine-2-carbonyl)oxyphenyl] 2-O-methyl pyridine-2,6-dicarboxylate | |
0.0016 | - |
in 100 mM Tris-Tricine, pH 8.5, temperature not specified in the publication | Mycobacterium tuberculosis | 2-N',2-N',7-N',7-N'-tetramethyl-9H-fluorene-2,7-disulfonohydrazide | |
0.0026 | - |
in 100 mM Tris-Tricine, pH 8.5, temperature not specified in the publication | Mycobacterium tuberculosis | ethyl 3-(pyridin-2-ylthio)propanoate | |
0.0028 | - |
in 100 mM Tris-Tricine, pH 8.5, temperature not specified in the publication | Mycobacterium tuberculosis | 2-(hydoxyimino)-6-methyl-2H-benzopyran-3-carboxamide | |
0.0033 | - |
in 100 mM Tris-Tricine, pH 8.5, temperature not specified in the publication | Mycobacterium tuberculosis | 2-(4-methoxyphenyl)-1-morpholin-4-ylethanethione | |
0.0049 | - |
in 100 mM Tris-Tricine, pH 8.5, temperature not specified in the publication | Mycobacterium tuberculosis | 1,1'-(2-oxido-1,2,5-oxadiazole-3,4-diyl)-bis (1-(2-thienyl))-methanone | |
0.0052 | - |
in 100 mM Tris-Tricine, pH 8.5, temperature not specified in the publication | Mycobacterium tuberculosis | 3,3-dihydroxy-1H-quinoline-2,4-dione | |
0.0057 | - |
in 100 mM Tris-Tricine, pH 8.5, temperature not specified in the publication | Mycobacterium tuberculosis | 2-(2-hydroxyphenoxy)-N-methylacetamide | |
0.006 | - |
in 100 mM Tris-Tricine, pH 8.5, temperature not specified in the publication | Mycobacterium tuberculosis | 2-phenyl-1-piperidin-1-ylethanethione | |
0.0065 | - |
in 100 mM Tris-Tricine, pH 8.5, temperature not specified in the publication | Mycobacterium tuberculosis | 2-(4-methylphenyl)-1-morpholin-4-ylethanethione | |
0.0068 | - |
in 100 mM Tris-Tricine, pH 8.5, temperature not specified in the publication | Mycobacterium tuberculosis | N-benzyl-5-chloro-2-methylsulfonylpyrimidine-4-carboxamide | |
0.0077 | - |
in 100 mM Tris-Tricine, pH 8.5, temperature not specified in the publication | Mycobacterium tuberculosis | 2-(4,6-dimethyl-3-oxo-[1,2]thiazolo[5,4-b]pyridin-2-yl)-N-[2-(4-ethoxyphenyl)ethyl]acetamide | |
0.0082 | - |
in 100 mM Tris-Tricine, pH 8.5, temperature not specified in the publication | Mycobacterium tuberculosis | 5-chloro-N-(3-chloro-4-methoxyphenyl)-2-(methylsulfonyl)pyrimidine-4-carboxamide | |
0.0082 | - |
in 100 mM Tris-Tricine, pH 8.5, temperature not specified in the publication | Mycobacterium tuberculosis | N-hydroxy-2-(2-hydroxyphenoxy)acetamide | |
0.009 | - |
in 100 mM Tris-Tricine, pH 8.5, temperature not specified in the publication | Mycobacterium tuberculosis | N',N',4-trimethylbenzenesulfonohydrazide | |
0.0131 | - |
in 100 mM Tris-Tricine, pH 8.5, temperature not specified in the publication | Mycobacterium tuberculosis | 2-(pyridin-3-ylcarbamothioyl sulfanyl)acetic acid | |
0.058 | - |
in 100 mM Tris-Tricine, pH 8.5, temperature not specified in the publication | Mycobacterium tuberculosis | (4R)-4-amino-3-isoxazolidinone |
General Information | Comment | Organism |
---|---|---|
physiological function | alanine racemase plays an essential role in cell wall synthesis as it racemizes L-alanine into D-alanine, a key building block in the biosynthesis of peptidoglycan | Mycobacterium tuberculosis |