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Literature summary for 5.1.1.1 extracted from

  • Im, H.; Sharpe, M.L.; Strych, U.; Davlieva, M.; Krause, K.L.
    The crystal structure of alanine racemase from Streptococcus pneumoniae, a target for structure-based drug design (2011), BMC Microbiol., 11, 116.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine since it is absent in humans, this enzyme is an attractive target for the development of drugs against Streptococcus pneumoniae and other bacterial pathogens Streptococcus pneumoniae

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21(DE3) pLysS cells Streptococcus pneumoniae

Crystallization (Commentary)

Crystallization (Comment) Organism
sitting drop vapor diffusion method, at 4°C in 1.2 M sodium citrate, 0.1 M MES, pH 7.2, and 10% (v/v) glycerol Streptococcus pneumoniae

Organism

Organism UniProt Comment Textmining
Streptococcus pneumoniae P0A2W8
-
-

Purification (Commentary)

Purification (Comment) Organism
ammonium sulfate precipitation, anion-exchange chromatography, hydrophobic interaction chromatography, and gel filtration Streptococcus pneumoniae

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-alanine
-
Streptococcus pneumoniae D-alanine
-
?

Subunits

Subunits Comment Organism
homodimer x-ray crystallography Streptococcus pneumoniae

Synonyms

Synonyms Comment Organism
ALR
-
Streptococcus pneumoniae

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate
-
Streptococcus pneumoniae