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Literature summary for 5.1.1.1 extracted from

  • Rubinstein, A.; Major, D.T.
    Understanding catalytic specificity in alanine racemase from quantum mechanical and molecular mechanical simulations of the arginine 219 mutant (2010), Biochemistry, 49, 3957-3964.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
R219E catalytical active mutant, the catalytic effect in the Arg219Glu mutant enzyme is due to a combined solvent and inherent stabilizing effect of the protonated cofactor, in contrast to the wild-type enzyme where the catalytic effect may be ascribed to solvent effects alone Geobacillus stearothermophilus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-alanine Geobacillus stearothermophilus
-
D-alanine
-
r

Organism

Organism UniProt Comment Textmining
Geobacillus stearothermophilus P10724
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-alanine
-
Geobacillus stearothermophilus D-alanine
-
r

Subunits

Subunits Comment Organism
homodimer computational simulations Geobacillus stearothermophilus

General Information

General Information Comment Organism
metabolism biosynthesis of D-alanine as building blocks in the peptidoglycan layers of bacterial cell walls Geobacillus stearothermophilus