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Literature summary for 5.1.1.1 extracted from

  • Strych, U.; Huang, H.C.; Krause, K.L.; Benedik, M.J.
    Characterization of the alanine racemases from Pseudomonas aeruginosa PAO1 (2000), Curr. Microbiol., 41, 290-294.
    View publication on PubMed

Application

Application Comment Organism
medicine the requirement for D-Ala as a necessary component of the bacterial cell wall makes the enzyme a logical target for the development of novel antibiotics Pseudomonas aeruginosa

Cloned(Commentary)

Cloned (Comment) Organism
cloning of two independent alanine racemases in Escherichia coli: Alr and DadX Pseudomonas aeruginosa

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1
-
L-Ala 23°C, enzyme Alr Pseudomonas aeruginosa
1.1
-
D-Ala 23°C, enzyme Alr Pseudomonas aeruginosa
1.4
-
L-Ala 23°C, enzyme DadX Pseudomonas aeruginosa
1.4
-
D-Ala 23°C, enzyme DadX Pseudomonas aeruginosa

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-Ala Pseudomonas aeruginosa enzyme is required for production of D-Ala, a necessary component of the bacterial cell wall D-Ala
-
?

Organism

Organism UniProt Comment Textmining
Pseudomonas aeruginosa
-
PAO1, two independent alanine racemases: DadX and Alr
-

Purification (Commentary)

Purification (Comment) Organism
recombinant enzymes Alr and DadX Pseudomonas aeruginosa

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-Ala
-
Pseudomonas aeruginosa D-Ala
-
r
L-Ala enzyme is required for production of D-Ala, a necessary component of the bacterial cell wall Pseudomonas aeruginosa D-Ala
-
?

Synonyms

Synonyms Comment Organism
ALR
-
Pseudomonas aeruginosa
DadX
-
Pseudomonas aeruginosa