Activating Compound | Comment | Organism | Structure |
---|---|---|---|
heme | heme receptor mediates the stimulatory effect of heme on the (Na+ + K+)ATPase activity through a PIPLC/PKC signaling pathway | Leishmania amazonensis |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
ET-18-OCH3 | specific inhibitors of PI-PLC, 0.1 mM abolish stimulatory effect of 0.00005 mM heme in the PI-PLC/protein kinase C pathway | Leishmania amazonensis | |
U73122 | specific inhibitors of PI-PLC, 0.05 mM abolish stimulatory effect of heme in the PI-PLC/protein kinase C pathway | Leishmania amazonensis |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Leishmania amazonensis | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
promastigote | - |
Leishmania amazonensis | - |
Synonyms | Comment | Organism |
---|---|---|
phosphatidylinositol-specific phospholipase C | - |
Leishmania amazonensis |
phosphatidylinositol-specific PLC | - |
Leishmania amazonensis |
PI-PLC | - |
Leishmania amazonensis |
General Information | Comment | Organism |
---|---|---|
physiological function | PI-PLC pathway is involved in the stimulatory effect of heme on (Na+ + K+)ATPase via PKC-like activation | Leishmania amazonensis |