Application | Comment | Organism |
---|---|---|
medicine | isoform ACbeta represents a potential target for development of safe and effective antimalarial therapeutics | Plasmodium falciparum |
Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli Top10 cells | Plasmodium falciparum |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-hydroxyestradiol | - |
Plasmodium falciparum | |
KH7 | potent, specific inhibitor | Plasmodium falciparum |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mn2+ | optimum activity at 10 mM | Plasmodium falciparum |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP | Plasmodium falciparum | - |
3',5'-cyclic AMP + diphosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Plasmodium falciparum | - |
- |
- |
Purification (Comment) | Organism |
---|---|
glutathione Sepharose, column chromatography and Superdex G-25 gel filtration | Plasmodium falciparum |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP | - |
Plasmodium falciparum | 3',5'-cyclic AMP + diphosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ACbeta | - |
Plasmodium falciparum |
adenylyl cyclase-beta | - |
Plasmodium falciparum |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
- |
Plasmodium falciparum |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.005 | - |
at pH 7.5 and 37°C | Plasmodium falciparum | KH7 | |
0.008 | - |
at pH 7.5 and 37°C | Plasmodium falciparum | 2-hydroxyestradiol |
General Information | Comment | Organism |
---|---|---|
physiological function | adenylyl cyclase activity is required in early-mid erythrocytic stages and functions as the parasite's pH sensor during growth inside red blood cells | Plasmodium falciparum |