Literature summary for 4.6.1.1 extracted from

Salazar, E.; Bank, E.M.; Ramsey, N.; Hess, K.C.; Deitsch, K.W.; Levin, L.R.; Buck, J.
Characterization of Plasmodium falciparum adenylyl cyclase-beta and its role in erythrocytic stage parasites (2012), PLoS ONE, 7, e39769.

Search for more literature for 4.6.1.1

Application

Application	Comment	Organism
medicine	isoform ACbeta represents a potential target for development of safe and effective antimalarial therapeutics	Plasmodium falciparum

Cloned(Commentary)

Cloned (Comment)	Organism
expressed in Escherichia coli Top10 cells	Plasmodium falciparum

Inhibitors

Inhibitors	Comment	Organism	Structure
2-hydroxyestradiol	-	Plasmodium falciparum
KH7	potent, specific inhibitor	Plasmodium falciparum

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Mn2+	optimum activity at 10 mM	Plasmodium falciparum

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP	Plasmodium falciparum	-	3',5'-cyclic AMP + diphosphate	-	?

Organism

Organism	UniProt	Comment	Textmining
Plasmodium falciparum	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
glutathione Sepharose, column chromatography and Superdex G-25 gel filtration	Plasmodium falciparum

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP	-	Plasmodium falciparum	3',5'-cyclic AMP + diphosphate	-	?

Synonyms

Synonyms	Comment	Organism
ACbeta	-	Plasmodium falciparum
adenylyl cyclase-beta	-	Plasmodium falciparum

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
7.5	-	-	Plasmodium falciparum

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.005	-	at pH 7.5 and 37°C	Plasmodium falciparum	KH7
0.008	-	at pH 7.5 and 37°C	Plasmodium falciparum	2-hydroxyestradiol

General Information

General Information	Comment	Organism
physiological function	adenylyl cyclase activity is required in early-mid erythrocytic stages and functions as the parasite's pH sensor during growth inside red blood cells	Plasmodium falciparum

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)