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Literature summary for 4.6.1.1 extracted from

  • Imber, A.N.; Santin, J.M.; Graham, C.D.; Putnam, R.W.
    A HCO3--dependent mechanism involving soluble adenylyl cyclase for the activation of Ca2+ currents in locus coeruleus neurons (2014), Biochim. Biophys. Acta, 1842, 2569-2578.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 4.6.1.1

Inhibitors

Inhibitors Comment Organism Structure
2-(1H-benzo[d]imidazole-2-ylthio)-N'-(5-bromo-2-hydroxybenzylidene) propanehydrazide 0.07 mM used in assay conditions Rattus norvegicus
2-hydroxyestradiol 0.01 mM used in assay conditions Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
 Rattus norvegicus 5737
-
soluble
-
 Rattus norvegicus
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP Rattus norvegicus
-
 3',5'-cyclic AMP + diphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
neuron locus coeruleus neuron Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP
-
 Rattus norvegicus 3',5'-cyclic AMP + diphosphate
-
 ?

Synonyms

Synonyms Comment Organism
sAC
-
 Rattus norvegicus
soluble adenylyl cyclase
-
 Rattus norvegicus

General Information

General Information Comment Organism
physiological function the enzyme is involved in the activation of L-type Ca2+ channels in a HCO3--dependent braking pathway that results in elevated intracellular Ca2+ and activation of BK channels Rattus norvegicus