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Literature summary for 4.6.1.1 extracted from

  • Geduhn, J.; Dove, S.; Shen, Y.; Tang, W.J.; Koenig, B.; Seifert, R.
    Bis-halogen-anthraniloyl-substituted nucleoside 5-triphosphates as potent and selective inhibitors of Bordetella pertussis adenylyl cyclase toxin (2011), J. Pharmacol. Exp. Ther., 336, 104-115.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 4.6.1.1

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Sf9 insect cells Bordetella pertussis

Inhibitors

Inhibitors Comment Organism Structure
2',3'-O-bis(5-acetamidoanthraniloyl)-ATP
-
 Bordetella pertussis
2',3'-O-bis(5-bromoanthraniloyl)-ADP
-
 Bordetella pertussis
2',3'-O-bis(5-bromoanthraniloyl)-ATP
-
 Bordetella pertussis
2',3'-O-bis(5-bromoanthraniloyl)-ITP
-
 Bordetella pertussis
2',3'-O-bis(5-chloroanthraniloyl)-ATP
-
 Bordetella pertussis
2',3'-O-bis(5-chloroanthraniloyl)-ITP
-
 Bordetella pertussis
2',3'-O-bis(5-methylanthraniloyl)-ADP
-
 Bordetella pertussis
2',3'-O-bis(5-methylanthraniloyl)-ATP
-
 Bordetella pertussis
2',3'-O-bis(5-methylanthraniloyl)-CTP
-
 Bordetella pertussis
2',3'-O-bis(5-methylanthraniloyl)-IDP
-
 Bordetella pertussis
2',3'-O-bis(5-methylanthraniloyl)-IMP
-
 Bordetella pertussis
2',3'-O-bis(5-methylanthraniloyl)-ITP
-
 Bordetella pertussis
2',3'-O-bis(5-propylanthraniloyl)-ATP
-
 Bordetella pertussis
2',3'-O-bis(5-propylanthraniloyl)-ITP
-
 Bordetella pertussis
2',3'-O-bis-anthraniloyl-IMP
-
 Bordetella pertussis
3'-O-(5-acetamidoanthraniloyl)-ATP
-
 Bordetella pertussis
3'-O-(5-acetamidoanthraniloyl)-ITP
-
 Bordetella pertussis
3'-O-(5-bromoanthraniloyl)-ADP
-
 Bordetella pertussis
3'-O-(5-bromoanthraniloyl)-ATP
-
 Bordetella pertussis
3'-O-(5-bromoanthraniloyl)-ITP
-
 Bordetella pertussis
3'-O-(5-chloroanthraniloyl)-ATP
-
 Bordetella pertussis
3'-O-(5-chloroanthraniloyl)-ITP
-
 Bordetella pertussis
3'-O-(5-propylanthraniloyl)-ATP
-
 Bordetella pertussis
3'-O-(5-propylanthraniloyl)-ITP
-
 Bordetella pertussis
anthraniloyl-IMP
-
 Bordetella pertussis
bis-acetamido-anthraniloyl-ITP
-
 Bordetella pertussis
methylanthraniloyl-ADP
-
 Bordetella pertussis
methylanthraniloyl-ATP
-
 Bordetella pertussis
methylanthraniloyl-CTP
-
 Bordetella pertussis
methylanthraniloyl-IDP
-
 Bordetella pertussis
methylanthraniloyl-IMP
-
 Bordetella pertussis
methylanthraniloyl-ITP
-
 Bordetella pertussis
additional information not inhibited by methylanthraniloyl-IMP and anthraniloyl-IMP Bordetella pertussis

Organism

Organism UniProt Comment Textmining
Bordetella pertussis
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP
-
 Bordetella pertussis 3',5'-cyclic-AMP + diphosphate
-
 ?

Synonyms

Synonyms Comment Organism
AC toxin
-
 Bordetella pertussis
adenylyl cyclase
-
 Bordetella pertussis
CyaA
-
 Bordetella pertussis

Cofactor

Cofactor Comment Organism Structure
Calmodulin
-
 Bordetella pertussis

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0000126
-
 2',3'-O-bis(5-bromoanthraniloyl)-ATP in 75 mM HEPES/NaOH, pH 7.4, at 25°C Bordetella pertussis
0.000015
-
 2',3'-O-bis(5-chloroanthraniloyl)-ITP in 75 mM HEPES/NaOH, pH 7.4, at 25°C Bordetella pertussis
0.000016
-
 2',3'-O-bis(5-chloroanthraniloyl)-ATP in 75 mM HEPES/NaOH, pH 7.4, at 25°C Bordetella pertussis
0.00002
-
 2',3'-O-bis(5-bromoanthraniloyl)-ITP in 75 mM HEPES/NaOH, pH 7.4, at 25°C Bordetella pertussis
0.000091
-
 2',3'-O-bis(5-bromoanthraniloyl)-ADP in 75 mM HEPES/NaOH, pH 7.4, at 25°C Bordetella pertussis
0.00028
-
 2',3'-O-bis(5-acetamidoanthraniloyl)-ATP in 75 mM HEPES/NaOH, pH 7.4, at 25°C Bordetella pertussis
0.00033
-
 3'-O-(5-bromoanthraniloyl)-ATP in 75 mM HEPES/NaOH, pH 7.4, at 25°C Bordetella pertussis
0.00035
-
 3'-O-(5-chloroanthraniloyl)-ATP in 75 mM HEPES/NaOH, pH 7.4, at 25°C Bordetella pertussis
0.00036
-
 2',3'-O-bis(5-methylanthraniloyl)-ATP in 75 mM HEPES/NaOH, pH 7.4, at 25°C Bordetella pertussis
0.0006
-
 methylanthraniloyl-ITP in 75 mM HEPES/NaOH, pH 7.4, at 25°C Bordetella pertussis
0.0007
-
 3'-O-(5-chloroanthraniloyl)-ITP in 75 mM HEPES/NaOH, pH 7.4, at 25°C Bordetella pertussis
0.0007
-
 2',3'-O-bis(5-propylanthraniloyl)-ATP in 75 mM HEPES/NaOH, pH 7.4, at 25°C Bordetella pertussis
0.00071
-
 3'-O-(5-acetamidoanthraniloyl)-ATP in 75 mM HEPES/NaOH, pH 7.4, at 25°C Bordetella pertussis
0.00082
-
 3'-O-(5-propylanthraniloyl)-ATP in 75 mM HEPES/NaOH, pH 7.4, at 25°C Bordetella pertussis
0.00092
-
 3'-O-(5-bromoanthraniloyl)-ITP in 75 mM HEPES/NaOH, pH 7.4, at 25°C Bordetella pertussis
0.0011
-
 methylanthraniloyl-CTP in 75 mM HEPES/NaOH, pH 7.4, at 25°C Bordetella pertussis
0.0021
-
 2',3'-O-bis(5-propylanthraniloyl)-ITP in 75 mM HEPES/NaOH, pH 7.4, at 25°C Bordetella pertussis
0.0025
-
 2',3'-O-bis(5-methylanthraniloyl)-CTP in 75 mM HEPES/NaOH, pH 7.4, at 25°C Bordetella pertussis
0.003
-
 2',3'-O-bis(5-methylanthraniloyl)-ITP in 75 mM HEPES/NaOH, pH 7.4, at 25°C Bordetella pertussis
0.0038
-
 3'-O-(5-propylanthraniloyl)-ITP in 75 mM HEPES/NaOH, pH 7.4, at 25°C Bordetella pertussis
0.0043
-
 methylanthraniloyl-ATP in 75 mM HEPES/NaOH, pH 7.4, at 25°C Bordetella pertussis
0.0048
-
 3'-O-(5-acetamidoanthraniloyl)-ITP in 75 mM HEPES/NaOH, pH 7.4, at 25°C Bordetella pertussis
0.0065
-
 2',3'-O-bis(5-methylanthraniloyl)-ADP in 75 mM HEPES/NaOH, pH 7.4, at 25°C Bordetella pertussis
0.0066
-
 2',3'-O-bis(5-methylanthraniloyl)-IDP in 75 mM HEPES/NaOH, pH 7.4, at 25°C Bordetella pertussis
0.0075
-
 bis-acetamido-anthraniloyl-ITP in 75 mM HEPES/NaOH, pH 7.4, at 25°C Bordetella pertussis
0.0087
-
 3'-O-(5-bromoanthraniloyl)-ADP in 75 mM HEPES/NaOH, pH 7.4, at 25°C Bordetella pertussis
0.011
-
 methylanthraniloyl-IDP in 75 mM HEPES/NaOH, pH 7.4, at 25°C Bordetella pertussis
0.012
-
 methylanthraniloyl-ADP in 75 mM HEPES/NaOH, pH 7.4, at 25°C Bordetella pertussis
0.012
-
 2',3'-O-bis-anthraniloyl-IMP in 75 mM HEPES/NaOH, pH 7.4, at 25°C Bordetella pertussis
0.02
-
 2',3'-O-bis(5-methylanthraniloyl)-IMP in 75 mM HEPES/NaOH, pH 7.4, at 25°C Bordetella pertussis