Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 4.6.1.1 extracted from

  • Fuss, N.; Mujagic, S.; Erber, J.; Wachten, S.; Baumann, A.
    Biochemical properties of heterologously expressed and native adenylyl cyclases from the honeybee brain (Apis mellifera L.) (2010), Insect Biochem. Mol. Biol., 40, 573-580.
    View publication on PubMed
Search for more literature for 4.6.1.1

Activating Compound

Activating Compound Comment Organism Structure
NKH477 half-maximal activation with NKH477 is in the low micromolar range with 0.0102 mM for isoform AC3 and 0.0036-0.0081 mM for native enzyme Apis mellifera

Inhibitors

Inhibitors Comment Organism Structure
2',5'-dd-3'-ATP most potent inhibitor Apis mellifera
2'-deoxyadenosine
-
 Apis mellifera
3'-AMP
-
 Apis mellifera
adenosine
-
 Apis mellifera
Ca2+/calmodulin the Ca2+/calmodulin inhibition of isoform AC3 occurs at rather high concentrations (0.1 mM/0.0005 mM) Apis mellifera

Metals/Ions

Metals/Ions Comment Organism Structure
additional information the basal activity of isoform AC3 does not change in the presence of Ca2+ or Ca2+/calmodulin Apis mellifera

Organism

Organism UniProt Comment Textmining
Apis mellifera
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
antennal lobe glomeruli of the antennal lobes are specifically stained, whereas the core of the antennal lobes displays only weak labeling Apis mellifera
-
brain
-
 Apis mellifera
-
cerebrum
-
 Apis mellifera
-
neutrophil isoform AC3 is evenly distributed in different sensory, central and motor neuropils Apis mellifera
-
subesophageal ganglion
-
 Apis mellifera
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP
-
 Apis mellifera 3',5'-cyclic-AMP + diphosphate
-
 ?

Synonyms

Synonyms Comment Organism
AC3 isoform Apis mellifera
adenylyl cyclase
-
 Apis mellifera

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000165
-
 in 10 mM Tris-HCl pH 7.5, at 30°C Apis mellifera 2',5'-dd-3'-ATP
0.0302
-
 in 10 mM Tris-HCl pH 7.5, at 30°C Apis mellifera 3'-AMP
0.07
-
 in 10 mM Tris-HCl pH 7.5, at 30°C Apis mellifera 2'-deoxyadenosine
0.095
-
 in 10 mM Tris-HCl pH 7.5, at 30°C Apis mellifera adenosine

General Information

General Information Comment Organism
physiological function isoform AC3 is a likely candidate to fulfill an integrative role in sensory, motor and higher-order information processing in the honeybee brain Apis mellifera