Literature summary for 4.6.1.1 extracted from

Sugano, Y.; Lai, N.C.; Gao, M.H.; Firth, A.L.; Yuan, J.X.; Lew, W.Y.; Hammond, H.K.
Activated expression of cardiac adenylyl cyclase 6 reduces dilation and dysfunction of the pressure-overloaded heart (2011), Biochem. Biophys. Res. Commun., 405, 349-355.

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Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
heart	-	Mus musculus	-

Synonyms

Synonyms	Comment	Organism
AC6	isoform	Mus musculus
adenylyl cyclase 6	isoform	Mus musculus

Cofactor

Cofactor	Comment	Organism	Structure
Calmodulin	-	Mus musculus

General Information

General Information	Comment	Organism
physiological function	cardiac-directed adenylyl cyclase 6 expression attenuates left ventricular hypertrophy and dysfunction in cardiomyopathy. Left ventricular contractility is increased, diastolic function is improved and left ventricular dilation is reduced by activation of adenylyl cyclase 6 expression	Mus musculus

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Release 2023.1 (January 2023)