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Literature summary for 4.6.1.1 extracted from

  • Ryzhov, S.; Zaynagetdinov, R.; Goldstein, A.E.; Matafonov, A.; Biaggioni, I.; Feoktistov, I.
    Differential role of the carboxy-terminus of the A(2B) adenosine receptor in stimulation of adenylate cyclase, phospholipase Cbeta, and interleukin-8 (2009), Purinergic Signal., 5, 289-298.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 4.6.1.1

Activating Compound

Activating Compound Comment Organism Structure
A2B adenosine receptor activates the enzyme and regulates its activity and the cAMP signaling pathway in mast and microvascular cell, role of the C-terminus of the A2B receptor in stimulation of adenylate cyclase, which is important for A2B receptor coupling to Gs-adenylate cyclase, overview Cricetulus griseus
A2B adenosine receptor activates the enzyme and regulates its activity and the cAMP signaling pathway in mast and microvascular cell, role of the C-terminus of the A2B receptor in stimulation of adenylate cyclase, which is important for A2B receptor coupling to Gs-adenylate cyclase, overview Homo sapiens
forskolin free G protein Gsalpha subunits enhance adenylate cyclase responses to forskolin Cricetulus griseus
forskolin free G protein Gsalpha subunits enhance adenylate cyclase responses to forskolin Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Cricetulus griseus 16020
-
membrane
-
 Homo sapiens 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP Cricetulus griseus
-
 3',5'-cyclic-AMP + diphosphate
-
 ?
ATP Homo sapiens
-
 3',5'-cyclic-AMP + diphosphate
-
 ?
additional information Cricetulus griseus the A2B adenosine receptor controls at least three independent signaling pathways, one of which is the Gs-mediated stimulation of adenylate cyclase, in mast cells and microvascular endothelial cells ?
-
 ?
additional information Homo sapiens the A2B adenosine receptor controls at least three independent signaling pathways, one of which is the Gs-mediated stimulation of adenylate cyclase, in mast cells and microvascular endothelial cells ?
-
 ?

Organism

Organism UniProt Comment Textmining
Cricetulus griseus
-
-
-
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
CHO cell
-
 Cricetulus griseus
-
HEK-293 cell
-
 Homo sapiens
-
mast cell
-
 Homo sapiens
-
microvascular endothelial cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP
-
 Cricetulus griseus 3',5'-cyclic-AMP + diphosphate
-
 ?
ATP
-
 Homo sapiens 3',5'-cyclic-AMP + diphosphate
-
 ?
additional information the A2B adenosine receptor controls at least three independent signaling pathways, one of which is the Gs-mediated stimulation of adenylate cyclase, in mast cells and microvascular endothelial cells Cricetulus griseus ?
-
 ?
additional information the A2B adenosine receptor controls at least three independent signaling pathways, one of which is the Gs-mediated stimulation of adenylate cyclase, in mast cells and microvascular endothelial cells Homo sapiens ?
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Cricetulus griseus
37
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Cricetulus griseus
7.4
-
 assay at Homo sapiens