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Literature summary for 4.6.1.1 extracted from

  • Dwivedi, Y.; Pandey, G.N.
    Adenylyl cyclase-cyclicAMP signaling in mood disorders: Role of the crucial phosphorylating enzyme protein kinase A (2008), Neuropsychiatr. Disease Treat., 4, 161-176.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 4.6.1.1

Activating Compound

Activating Compound Comment Organism Structure
forskolin
-
 Homo sapiens
additional information binding of agonists to receptors leads to the activation of G proteins, which in turn activate adenylyl cyclase, overview Homo sapiens
protein kinase A stimulates cAMP in the brain, the activation is increased in brains of patients with bipolar mood disorders, overview Homo sapiens
stimulating G protein both alpha and betagamma subunits, activated by GTP binding, can modulate activity of effectors in transduction signaling, including adenylyl cyclase. In depressed patients, the expression of stimulatory G protein is increased and of inhibitory G protein is decreased, which suggests greater stimulation of the cAMP pathway Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
inhibitory G protein both alpha and betagamma subunits, activated by GTP binding, can modulate activity of effectors in transduction signaling, including adenylyl cyclase. In depressed patients, the expression of stimulatory G protein is increased and of inhibitory G protein is decreased, which suggests greater stimulation of the cAMP pathway Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
plasma membrane
-
 Homo sapiens 5886
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP Homo sapiens most of the effects of cAMP are mediated by its receptor protein kinase A, PKA, cAMP serves as a second messenger and activates the phosphorylation enzyme PKA. The enzyme is part of the adenylyl cyclase-cyclicAMP signaling system, which is implicated in synaptic and structural plasticity and utilized by a number of neurotransmitter receptors, including serotonergic and adrenergic, to mediate their physiological functions, detailed overview. Cross-talk between the AC-cAMP and other signaling systems 3',5'-cyclic-AMP + diphosphate
-
 ?
additional information Homo sapiens adenylyl cyclase and cAMP formation in mood disorders and the role of the enzyme protein kinase A, mood disorders are among the most prevalent and recurrent forms of psychiatric illnesses, mechanistic basics, overview. In depressed patients, the expression of stimulatory G protein is increased and of inhibitory G protein is decreased, which suggests greater stimulation of the cAMP pathway ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein protein kinase A stimulates cAMP in the brain, the activation is increased in brains of patients with bipolar mood disorders, overview Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP
-
 Homo sapiens 3',5'-cyclic-AMP + diphosphate
-
 ?
ATP most of the effects of cAMP are mediated by its receptor protein kinase A, PKA, cAMP serves as a second messenger and activates the phosphorylation enzyme PKA. The enzyme is part of the adenylyl cyclase-cyclicAMP signaling system, which is implicated in synaptic and structural plasticity and utilized by a number of neurotransmitter receptors, including serotonergic and adrenergic, to mediate their physiological functions, detailed overview. Cross-talk between the AC-cAMP and other signaling systems Homo sapiens 3',5'-cyclic-AMP + diphosphate
-
 ?
additional information adenylyl cyclase and cAMP formation in mood disorders and the role of the enzyme protein kinase A, mood disorders are among the most prevalent and recurrent forms of psychiatric illnesses, mechanistic basics, overview. In depressed patients, the expression of stimulatory G protein is increased and of inhibitory G protein is decreased, which suggests greater stimulation of the cAMP pathway Homo sapiens ?
-
 ?