Activating Compound | Comment | Organism | Structure |
---|---|---|---|
forskolin | - |
Homo sapiens | |
additional information | binding of agonists to receptors leads to the activation of G proteins, which in turn activate adenylyl cyclase, overview | Homo sapiens | |
protein kinase A | stimulates cAMP in the brain, the activation is increased in brains of patients with bipolar mood disorders, overview | Homo sapiens | |
stimulating G protein | both alpha and betagamma subunits, activated by GTP binding, can modulate activity of effectors in transduction signaling, including adenylyl cyclase. In depressed patients, the expression of stimulatory G protein is increased and of inhibitory G protein is decreased, which suggests greater stimulation of the cAMP pathway | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
inhibitory G protein | both alpha and betagamma subunits, activated by GTP binding, can modulate activity of effectors in transduction signaling, including adenylyl cyclase. In depressed patients, the expression of stimulatory G protein is increased and of inhibitory G protein is decreased, which suggests greater stimulation of the cAMP pathway | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
plasma membrane | - |
Homo sapiens | 5886 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP | Homo sapiens | most of the effects of cAMP are mediated by its receptor protein kinase A, PKA, cAMP serves as a second messenger and activates the phosphorylation enzyme PKA. The enzyme is part of the adenylyl cyclase-cyclicAMP signaling system, which is implicated in synaptic and structural plasticity and utilized by a number of neurotransmitter receptors, including serotonergic and adrenergic, to mediate their physiological functions, detailed overview. Cross-talk between the AC-cAMP and other signaling systems | 3',5'-cyclic-AMP + diphosphate | - |
? | |
additional information | Homo sapiens | adenylyl cyclase and cAMP formation in mood disorders and the role of the enzyme protein kinase A, mood disorders are among the most prevalent and recurrent forms of psychiatric illnesses, mechanistic basics, overview. In depressed patients, the expression of stimulatory G protein is increased and of inhibitory G protein is decreased, which suggests greater stimulation of the cAMP pathway | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | protein kinase A stimulates cAMP in the brain, the activation is increased in brains of patients with bipolar mood disorders, overview | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP | - |
Homo sapiens | 3',5'-cyclic-AMP + diphosphate | - |
? | |
ATP | most of the effects of cAMP are mediated by its receptor protein kinase A, PKA, cAMP serves as a second messenger and activates the phosphorylation enzyme PKA. The enzyme is part of the adenylyl cyclase-cyclicAMP signaling system, which is implicated in synaptic and structural plasticity and utilized by a number of neurotransmitter receptors, including serotonergic and adrenergic, to mediate their physiological functions, detailed overview. Cross-talk between the AC-cAMP and other signaling systems | Homo sapiens | 3',5'-cyclic-AMP + diphosphate | - |
? | |
additional information | adenylyl cyclase and cAMP formation in mood disorders and the role of the enzyme protein kinase A, mood disorders are among the most prevalent and recurrent forms of psychiatric illnesses, mechanistic basics, overview. In depressed patients, the expression of stimulatory G protein is increased and of inhibitory G protein is decreased, which suggests greater stimulation of the cAMP pathway | Homo sapiens | ? | - |
? |