Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 4.6.1.1 extracted from

  • Wang, H.; Wu, L.J.; Zhang, F.; Zhuo, M.
    Roles of calcium-stimulated adenylyl cyclase and calmodulin-dependent protein kinase IV in the regulation of FMRP by group I metabotropic glutamate receptors (2008), J. Neurosci., 28, 4385-4397.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 4.6.1.1

Activating Compound

Activating Compound Comment Organism Structure
Calmodulin activates isozyme AC1 Mus musculus
Calmodulin activates isozyme AC8 Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information increase of Fmr1 mRNA is attenuated in ACC slices from AC1 KO mice compared to wild-type mice, and induced phosphorylation of CREB is significantly attenuated in ACC slices from AC1 KO mice compared with WT mice Mus musculus
additional information the basal phosphorylation levels of CREB are not changed in ACC slices from AC8 KO mice Mus musculus

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ activates isozyme AC1 Mus musculus
Ca2+ activates isozyme AC8 Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP Mus musculus roles of calcium-stimulated adenylyl cyclase and calmodulin-dependent protein kinase IV in the upregulation of fragile X mental retardation protein, FMRP, by group I metabotropic glutamate receptors, mGluRs, in anterior cingulate cortex neurons probably through cAMP response element-binding protein activation, calcium is critical for the regulation of FMRP by group I mGluRs, overview. Isozyme AC1 may contribute to the activation of CREB caused by stimulating group I mGluRs, overview 3',5'-cyclic-AMP + diphosphate
-
 ?
ATP Mus musculus roles of calcium-stimulated adenylyl cyclase and calmodulin-dependent protein kinase IV in the upregulation of fragile X mental retardation protein, FMRP, by group I metabotropic glutamate receptors, mGluRs, in anterior cingulate cortex neurons probably through cAMP response element-binding protein activation, calcium is critical for the regulation of FMRP by group I mGluRs, overview. Isozyme AC8 may contribute to the activation of CREB caused by stimulating group I mGluRs, overview 3',5'-cyclic-AMP + diphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus O88444 adult male C57BL/6 mice, isozyme AC1
-
Mus musculus P97490 adult male C57BL/6 mice, isozyme AC8
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Mus musculus
-
neuron anterior cingulate cortex, ACC, neurons from a key region involved in high brain cognitive and executive functions Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP
-
 Mus musculus 3',5'-cyclic-AMP + diphosphate
-
 ?
ATP roles of calcium-stimulated adenylyl cyclase and calmodulin-dependent protein kinase IV in the upregulation of fragile X mental retardation protein, FMRP, by group I metabotropic glutamate receptors, mGluRs, in anterior cingulate cortex neurons probably through cAMP response element-binding protein activation, calcium is critical for the regulation of FMRP by group I mGluRs, overview. Isozyme AC1 may contribute to the activation of CREB caused by stimulating group I mGluRs, overview Mus musculus 3',5'-cyclic-AMP + diphosphate
-
 ?
ATP roles of calcium-stimulated adenylyl cyclase and calmodulin-dependent protein kinase IV in the upregulation of fragile X mental retardation protein, FMRP, by group I metabotropic glutamate receptors, mGluRs, in anterior cingulate cortex neurons probably through cAMP response element-binding protein activation, calcium is critical for the regulation of FMRP by group I mGluRs, overview. Isozyme AC8 may contribute to the activation of CREB caused by stimulating group I mGluRs, overview Mus musculus 3',5'-cyclic-AMP + diphosphate
-
 ?

Synonyms

Synonyms Comment Organism
AC1
-
 Mus musculus
AC8
-
 Mus musculus
Ca2+/calmodulin-stimulated adenylyl cyclase 1
-
 Mus musculus
calcium-stimulated adenylyl cyclase
-
 Mus musculus